The relationship between atrial fibrillation and NLRP3 inflammasome: a gut microbiota perspective

Y Xing, L Yan, X Li, Z Xu, X Wu, H Gao, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) is a common clinical arrhythmia whose pathogenesis has not been fully
elucidated, and the inflammatory response plays an important role in the development of AF …

Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome

Y Zhang, S Zhang, B Li, Y Luo, Y Gong… - Cardiovascular …, 2022 - academic.oup.com
Aims Ageing is the most significant contributor to the increasing prevalence of atrial
fibrillation (AF). The gut microbiota dysbiosis is involved in age-related diseases. However …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

[PDF][PDF] Enhanced activation of inflammasome promotes atrial fibrillation

C Yao, L Scott, T Veleva, FU Müller, S Nattel… - Journal of Molecular …, 2017 - academia.edu
Background: Inflammation has been associated with the progression of atrial fibrillation (AF)
in patients, while the underlying molecular mechanisms remain elusive. It is known that a …

Targeting the NLRP3 inflammasome signalling for the management of atrial fibrillation

A Niskala, J Heijman, D Dobrev… - British Journal of …, 2024 - Wiley Online Library
Inflammatory signalling via the nod‐like receptor (NLR) family pyrin domain‐containing
protein‐3 (NLRP3) inflammasome has recently been implicated in the pathophysiology of …

Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation

N Li, BJJM Brundel - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …

Activation of NLRP3 inflammasome promotes atrial fibrillation

C Yao, L Scott, X Wehrens, D Dobrev, N Li - Circulation, 2016 - Am Heart Assoc
Introduction: Sterile inflammation is frequently observed in patients with atrial fibrillation (AF),
the most common cardiac arrhythmia. However, whether inflammation signaling plays a …

Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review

A Ajoolabady, S Nattel, GYH Lip, J Ren - Journal of the American College …, 2022 - jacc.org
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

D Dobrev, J Heijman, R Hiram, N Li… - Nature Reviews …, 2023 - nature.com
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

Research progress on the relationship between NLRP3 inflammasome and atrial fibrillation

YM Wang, W Wang, YF Tian… - Zhonghua xin xue …, 2021 - pubmed.ncbi.nlm.nih.gov
炎症在心房颤动 (房颤) 的发生, 发展过程中有重要作用. 炎症小体是先天免疫的重要组成部分,
参与多种病理生理学过程. NLRP3 炎症小体能够在多种类型的细胞中表达并发挥关键作用 …