Mitochondria are proving to be worthy targets for activating specific killing of cancer cells in
tumors and a diverse range of mitochondrial targeted drugs are currently in clinical trial to …

Nanotechnology has changed the entire paradigm of drug targeting and has shown
tremendous potential in the area of cancer therapy due to its specificity. In cancer, several …

Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …

Mitochondrion, the powerhouse of the cells, controls bioenergetics, biosynthesis,
metabolism, and signaling. Consequently, it has become an unorthodox target for cancer …

Mitochondria are double membrane-enveloped organelles that play a central role in cellular
metabolism, calcium homeostasis, redox signaling and cell fates. They function as main …

The tumor microenvironment affects the structure and metabolic function of mitochondria in
tumor cells. This process involves changes in metabolic activity, an increase in the amount …

The application of engineered bacteria-based drug delivery vehicles to treat cancer has
been practiced for more than a century. Mitochondria, evolutionarily originated from bacteria …

Mitochondria have recently emerged as novel targets for cancer therapy due to its important
roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow …

Simple Summary Cancer remains a major killer of the human population. Current cancer
diagnostic and therapeutic methods are associated with shortcomings of limited targetability …

There have been numerous efforts to develop targeted therapies for treating cancer. The
non-specificity of'classical'cytotoxic chemotherapy drugs and drug resistance remain major …