Celastrol, a natural triterpene, has been shown to treat obesity and its related metabolic
disorders. In this study, we first assessed the relationship between the antiobesity effects of …

Macrophage polarization is implicated in the inflammation in obesity. The aim of the present
study was to examine the anti-inflammatory activities of botanical triterpene celastrol against …

Objective Celastrol, a triterpene from the root bark of the Chinese medicinal plant
Tripterygium wilfordii, has been shown to exhibit anti-oxidant, anti-inflammatory, anti-cancer …

Botanical triterpene celastrol is a candidate drug for the treatment of obesity, except for
concerns over the safety in clinical application. The present study was designed to …

Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

Celastrol is a pentacyclic triterpenoid isolated from Tripterygium wilfordii that has long been
used in traditional Chinese medicine for treating rheumatoid arthritis. Previous studies …

Accumulating evidence indicates that adipose tissue inflammation and mitochondrial
dysfunction in skeletal muscle are inextricably linked to obesity and insulin resistance …

High fat diet, as an important risk factor, plays a pivotal role in atherosclerotic process.
Celastrol is one of the active triterpenoid compounds with antioxidative and anti …

Overweight and obesity may cause several metabolic complications, including type 2
diabetes mellitus and hyperlipidemia. Despite years of progress in medicine, there are no …

Background Obesity has become one of the most serious issues threatening the health of
humankind, and we conducted this study to examine whether and how celastrol protects …