There is growing interest in PEGylation of cationic polymeric vehicles for gene delivery in
order to improve vehicle stability and reduce toxicity, but little is known about the effects of …

A facile method for PEGylated bioreducible poly (amido amine) s is described by a one-pot
Michael-type addition polymerization of N, N′-cystaminebisacrylamide (CBA) with a …

While an effective non-viral gene carrier, 25kDa branched polyethylenimine (PEI) is
cytotoxic, and decreasing its toxicity while maintaining its functionality is vital. Conjugation of …

The influence of PEGylation on polyplex stability from poly (ethylene imine), PEI, and
plasmid DNA was investigated both in vitro and after intravenous administration in mice …

The effective delivery of DNA locally could increase the applicability of gene therapy in
tissue regeneration and therapeutic angiogenesis. One promising approach is through use …

Gene delivery is known to be a complicated multi-step biological process. It has been
observed that subtle differences in the structure and properties of polymeric materials used …

Polyplex-mediated gene therapy is a promising alternative to viral gene therapy. One
challenge to these synthetic carriers is reduced transfection efficiencies in vivo compared to …

In this study, we investigated galacturonic (GalAc)-and mannuronic (ManAc) acids as novel
targeting ligands for receptor-mediated gene delivery. GalAc and ManAc were coupled to …

In this study, we report the synthesis of well-defined model PEGylated poly
(dimethylaminoethyl methacrylate) based cationic polymers composed of different PEG …

Purpose A reversibly-PEGylated diblock copolymer, poly (aspartate-hydrazide-poly
(ethylene glycol))-block-poly (aspartate-diaminoethane)(p [Asp (Hyd-PEG)]-bp [Asp (DET)]) …