Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

Myocardial oxidative stress and Ca2+ overload induced by ischemia-reperfusion may be
involved in the development and progression of myocardial dysfunction in heart failure …

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …

We investigated whether xanthine oxidase (XO) is a major source of oxygen-derived free
radicals (oxy-radicals) in the pig and human skeletal muscles. It was observed that xanthine …

Reactive oxygen species (ROS) have been widely implicated in the pathogenesis of
diabetes and more recently in mitochondrial alterations in skeletal muscle of diabetic mice …

BACKGROUND: Oxidative stress is implicated in cardiac remodeling and failure. We tested
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …

The molecular basis for heart failure is unknown, but oxidative stress is associated with the
pathogenesis of the disease. We tested the hypothesis that the activity of xanthine …

Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …

Heart failure is a clinical syndrome associated with elevated levels of oxygen-derived free
radicals. Xanthine oxidase activity is believed to be one source of reactive oxygen species in …

BACKGROUND: Reactive oxygen species (ROS) have been linked to hypertrophy,
remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that …