Ischemia/reperfusion (I/R) injury is often responsible for delayed graft function after
transplantation. Trimetazidine (TMZ) is an anti-ischemic and antioxidant agent used to …

Background Xanthine oxidase (XO) is a cytosolic metalloflavoprotein that has been
implicated in the pathogenesis of a wide spectrum of diseases, and is thought to be the most …

We hypothesized that xanthine oxidase (XO)-derived hydrogen peroxide (H2O2) contributes
to ischemic skeletal muscle injury during reperfusion. We found that after ischemia (3 h) and …

Objective This research designed to analyze the in vivo and in silico ameliorative action of
maslinic acid (MA) and gallic acid (GA) on reactive oxygen species generating enzyme …

An investigation was made into the possible involvement of the enzyme xanthine oxidase
(XO)(EC 1.1. 3.22), both reversible (XOrev) and irreversible (XOirr), in damage observed …

Exercise could be a therapeutic approach for cardiovascular dysfunction induced by
estrogen deficiency. Our previous study has shown that estrogen maintains cystathionine-γ …

Background Dilated cardiomyopathy is characterized by an imbalance between left
ventricular performance and myocardial energy consumption. Experimental models suggest …

The accumulation of oxygen free radicals and activation of neutrophils are strongly
implicated as pathophysiological mechanisms mediating myocardial ischemia/reperfusion …

It has been reported that the production of oxygen radicals mediated by xanthine oxidase
(XO) is stimulated in hypertensive cardiovascular endothelium, suggesting involvement of …

Allopurinol, a xanthine oxidase (XO) inhibitor, is reported to alleviate myocardial
ischemia/reperfusion (I/R) injury by reducing the production of reactive oxygen species …