Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-old db/db mice by depleting cardiac glutathione

I Laher, J Beam, A Botta, R Barendregt… - Free radical …, 2013 - Taylor & Francis
Moderate exercise improves cardiac antioxidant status in young humans and animals with
Type-2 diabetes (T2D). Given that both diabetes and advancing age synergistically …

[HTML][HTML] Evaluation of the role of xanthine oxidase in myocardial reperfusion injury.

SL Thompson-Gorman, JL Zweier - Journal of Biological Chemistry, 1990 - Elsevier
The free radical-generating enzyme xanthine oxidase has been hypothesized to be a central
mechanism of the injury which occurs in postischemic tissues; however, its importance …

Metabolic alterations induce oxidative stress in diabetic and failing hearts: different pathways, same outcome

D Roul, FA Recchia - Antioxidants & Redox Signaling, 2015 - liebertpub.com
Significance: Several authors have proposed a link between altered cardiac energy
substrate metabolism and reactive oxygen species (ROS) generation. A cogent evidence of …

Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure

T Ukai, CP Cheng, H Tachibana, A Igawa, ZS Zhang… - Circulation, 2001 - Am Heart Assoc
Background—Superoxide (O2−) generated by enhanced xanthine oxidase (XO) activity may
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …

Clinical evidence of the association between serum perioperative changes in xanthine metabolizing enzymes activity and early post-transplant kidney allograft …

B Dołęgowska, W Błogowski, L Domański - Journal of the American College …, 2010 - Elsevier
BACKGROUND:: Xanthine oxidoreductase (XOR) and its active forms, dehydrogenase (XD)
and oxidase (XO), act as double-edged swords during ischemia-reperfusion injury. On the …

Thymoquinone attenuates cardiomyopathy in streptozotocin‐treated diabetic rats

MS Atta, AH El-Far, FA Farrag… - Oxidative medicine …, 2018 - Wiley Online Library
Diabetic cardiomyopathy is a diabetic complication due to oxidative stress injuries. This
study examined the protecting influence of thymoquinone (TQ) on diabetes‐caused cardiac …

NADPH oxidase inhibition prevents cocaine-induced up-regulation of xanthine oxidoreductase and cardiac dysfunction

M Isabelle, A Vergeade, F Moritz, B Dautréaux… - Journal of molecular and …, 2007 - Elsevier
Oxidative stress is involved in the pathogenesis of cocaine-induced cardiomyopathy. In the
present study, we aimed to determine the enzymatic sources of reactive oxygen species …

A novel function of nuclear nonmuscle myosin regulatory light chain in promotion of xanthine oxidase transcription after myocardial ischemia/reperfusion

YS Zhang, B Liu, XJ Luo, JJ Zhang, NS Li… - Free Radical Biology …, 2015 - Elsevier
Nuclear myosin regulates gene transcription and this novel function might be modulated
through phosphorylation of the myosin regulatory light chain (p-MLC 20). Nonmuscle MLC …

Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet

K Schröder, C Vecchione, O Jung, JG Schreiber… - Free Radical Biology …, 2006 - Elsevier
Hyperlipidemia enhances xanthine oxidase (XO) activity. XO is an important source of
reactive oxygen species (ROS). Since ROS are thought to promote atherosclerosis, we …

Role of oxidative stress in ischemia–reperfusion-induced alterations in myofibrillar ATPase activities and gene expression in the heart

S Maddika, V Elimban, D Chapman… - Canadian journal of …, 2009 - cdnsciencepub.com
Ischemia–reperfusion (IR) in the heart has been shown to produce myofibrillar remodeling
and depress Ca2+ sensitivity of myofilaments; however, the mechanisms for these …