Moderate exercise improves cardiac antioxidant status in young humans and animals with
Type-2 diabetes (T2D). Given that both diabetes and advancing age synergistically …

The free radical-generating enzyme xanthine oxidase has been hypothesized to be a central
mechanism of the injury which occurs in postischemic tissues; however, its importance …

Significance: Several authors have proposed a link between altered cardiac energy
substrate metabolism and reactive oxygen species (ROS) generation. A cogent evidence of …

Background—Superoxide (O2−) generated by enhanced xanthine oxidase (XO) activity may
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …

BACKGROUND:: Xanthine oxidoreductase (XOR) and its active forms, dehydrogenase (XD)
and oxidase (XO), act as double-edged swords during ischemia-reperfusion injury. On the …

Diabetic cardiomyopathy is a diabetic complication due to oxidative stress injuries. This
study examined the protecting influence of thymoquinone (TQ) on diabetes‐caused cardiac …

Oxidative stress is involved in the pathogenesis of cocaine-induced cardiomyopathy. In the
present study, we aimed to determine the enzymatic sources of reactive oxygen species …

Nuclear myosin regulates gene transcription and this novel function might be modulated
through phosphorylation of the myosin regulatory light chain (p-MLC 20). Nonmuscle MLC …

Hyperlipidemia enhances xanthine oxidase (XO) activity. XO is an important source of
reactive oxygen species (ROS). Since ROS are thought to promote atherosclerosis, we …

Ischemia–reperfusion (IR) in the heart has been shown to produce myofibrillar remodeling
and depress Ca2+ sensitivity of myofilaments; however, the mechanisms for these …