T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), mediating immune
exhaustion in tumor microenvironment, has become a promising target for tumor therapy …

The spatial organization of immune cells within the tumor microenvironment (TME) largely
determines the anti-tumor immunity and also highly predicts tumor progression and …

T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), a negative regulator
of antitumor immune response, has been demonstrated to be involved in the onset and …

ABSTRACT T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) is an important
immune regulatory molecule in cancer immune system. However, expression and function of …

One of the most common tumors in the world is hepatocellular carcinoma (HCC), and its
mortality rates are still on the rise, so addressing it is considered an important challenge for …

Both Tim-3 and Tim-4 belong to the T-cell immunoglobulin and mucin domain (Tim) gene
family, which plays a critical role in immunoregulation. Tim-3 has been suggested as a …

Over the past decade, cancer immunotherapy, such as immune checkpoint inhibitors (ICRs),
has attained considerable progresses in clinical practice. T-cell immunoglobulin and mucin …

T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates
innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer …

Purpose Renal cell carcinoma (RCC) is the most common cancer of kidney. Evidences have
shown that RCC is sensitive to various immunotherapies. Tim-3 plays a role in suppressing …

T‑cell immunoglobulin and mucin domain‑containing-3 (TIM‑3) performs a critical function in
immune tolerance by suppressing the activation and proliferation of T cells. TIM‑3 serves an …