Steps towards developing effective treatments for neuropsychiatric disturbances in Alzheimer's disease: Insights from preclinical models, clinical data, and future …

A Clement, O Wiborg, AA Asuni - Frontiers in Aging Neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia worldwide. It is mostly
known for its devastating effect on memory and learning but behavioral alterations …

[HTML][HTML] Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

KL Lanctôt, J Amatniek, S Ancoli-Israel… - Alzheimer's & Dementia …, 2017 - Elsevier
Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing
substantial distress for both people with dementia and their caregivers, and contributing to …

Alzheimer-related affective symptoms–mechanism and treatment

K Nitzan, D Frenkel, MO Parker… - Frontiers in aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia and the fifth leading cause
of death in adults older than 65. Aged individuals are disproportionately likely to suffer from …

Is bigger better? Towards a mechanistic understanding of neuropsychiatric symptoms in Alzheimer's disease

MA Nowrangi, PB Rosenberg - International psychogeriatrics, 2021 - cambridge.org
It is increasingly clear that the public health burden of Alzheimer's disease (AD) is not solely
due to cognitive decline but also to neuropsychiatric symptoms (NPS). NPS such as …

Elucidating the interactive roles of glia in Alzheimer's disease using established and newly developed experimental models

H Chun, I Marriott, CJ Lee, H Cho - Frontiers in Neurology, 2018 - frontiersin.org
Alzheimer's disease (AD) is an irreversible neurodegenerative illness and the exact etiology
of the disease remains unknown. It is characterized by long preclinical and prodromal …

Understanding neuropsychiatric symptoms in Alzheimer's disease: challenges and advances in diagnosis and treatment

A Pless, D Ware, S Saggu, H Rehman… - Frontiers in …, 2023 - frontiersin.org
Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) affect up to 97% of AD
patients, with an estimated 80% of current AD patients experiencing these symptoms …

Neuropsychiatric disturbances in Alzheimer's disease: what have we learned from neuropathological studies?

DV Dam, Y Vermeiren, AD Dekker… - Current Alzheimer …, 2016 - ingentaconnect.com
Neuropsychiatric symptoms (NPS) are an integral part of the dementia syndrome and were
therefore recently included in the core diagnostic criteria of dementia. The near universal …

Alzheimer's disease: A clinical perspective and future nonhuman primate research opportunities

RU Haque, AI Levey - … of the national Academy of Sciences, 2019 - National Acad Sciences
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is the sixth
leading cause of death and the most common cause of dementia worldwide. Over the last …

A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease

H Geerts, P Roberts, A Spiros, R Carr - Frontiers in pharmacology, 2013 - frontiersin.org
Successful disease modifying drug development for Alzheimer's disease (AD) has hit a
roadblock with the recent failures of amyloid-based therapies, highlighting the translational …

Beyond memory impairment: the complex phenotypic landscape of Alzheimer's disease

S Argyriou, JF Fullard, JM Krivinko, D Lee… - Trends in Molecular …, 2024 - cell.com
Abstract Neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD) constitute
multifaceted behavioral manifestations that reflect processes of emotional regulation …