Lipid nanoparticle technologies for nucleic acid delivery: A nanoarchitectonics perspective

AR Ferhan, S Park, H Park, H Tae… - Advanced Functional …, 2022 - Wiley Online Library
Lipid‐based nanoparticles have emerged as a clinically viable platform technology to
deliver nucleic acids for a wide range of healthcare applications. Within this scope, one of …

Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic

A Puri, K Loomis, B Smith, JH Lee… - Critical Reviews™ in …, 2009 - dl.begellhouse.com
In recent years, various nanotechnology platforms in the area of medical biology, including
both diagnostics and therapy, have gained remarkable attention. Moreover, research and …

[HTML][HTML] Design of lipid-based nanoparticles for delivery of therapeutic nucleic acids

MCP Mendonça, A Kont, PS Kowalski… - Drug Discovery …, 2023 - Elsevier
The successful development of nonviral delivery systems for nucleic acids has been
reported extensively over the past number of years. Among them, lipid-based nanoparticles …

[HTML][HTML] Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery

M Cárdenas, RA Campbell, MY Arteta… - Current Opinion in …, 2023 - Elsevier
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems,
notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined …

Lipid-based nanoparticles for drug/gene delivery: An overview of the production techniques and difficulties encountered in their industrial development

M Mehta, TA Bui, X Yang, Y Aksoy, EM Goldys… - ACS Materials …, 2023 - ACS Publications
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery
systems complementing conventional pharmacology has been widely acknowledged …

Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement

R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

Properties, engineering and applications of lipid-based nanoparticle drug-delivery systems: current research and advances

J Buse, A El-Aneed - Nanomedicine, 2010 - Taylor & Francis
Lipid-based drug-delivery systems have evolved from micro-to nano-scale, enhancing the
efficacy and therapeutic applications of these delivery systems. Production of lipid-based …

Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery

M Hu, X Li, Z You, R Cai, C Chen - Advanced Materials, 2024 - Wiley Online Library
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

Microfluidics for development of lipid nanoparticles: paving the way for nucleic acids to the clinic

MS Ali, N Hooshmand, M El-Sayed… - ACS Applied Bio …, 2021 - ACS Publications
Nucleic acid therapeutics hold an unprecedented promise toward treating many challenging
diseases; however, their use is hampered by delivery issues. Microfluidics, dealing with …

Lipid nanoparticles for drug delivery

L Xu, X Wang, Y Liu, G Yang… - Advanced …, 2022 - Wiley Online Library
Lipid nanoparticles have attracted significant interests in the last two decades, and have
achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the …