When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α, ω-diols in …

C Lu, C Batianis, EO Akwafo, RH Wijffels… - Biotechnology for …, 2021 - Springer
Background Medium-chain-length α, ω-diols (mcl-diols) are important building blocks in
polymer production. Recently, microbial mcl-diol production from alkanes was achieved in E …

[HTML][HTML] Microbial production of medium-chain-length α, ω-diols via two-stage process under mild conditions

C Lu, N Leitner, RH Wijffels, VAPM Dos Santos… - Bioresource …, 2022 - Elsevier
Medium-chain-length α, ω-diols (mcl-diols) are versatile compounds widely used as building
blocks of coating materials and polymers. Mcl-diols are currently synthesized through …

Pseudomonas putida as a platform for medium‐chain length α,ω‐diol production: Opportunities and challenges

C Lu, RH Wijffels, VAP Martins dos Santos… - Microbial …, 2024 - Wiley Online Library
Medium‐chain‐length α, ω‐diols (mcl‐diols) play an important role in polymer production,
traditionally depending on energy‐intensive chemical processes. Microbial cell factories …

Production of long chain alcohols and alkanes upon coexpression of an acyl-ACP reductase and aldehyde-deformylating oxygenase with a bacterial type-I fatty acid …

D Coursolle, J Lian, J Shanklin, H Zhao - Molecular BioSystems, 2015 - pubs.rsc.org
Microbial long chain alcohols and alkanes are renewable biofuels that could one day
replace petroleum-derived fuels. Here we report a novel pathway for high efficiency …

Bio-upcycling of even and uneven medium-chain-length diols and dicarboxylates to polyhydroxyalkanoates using engineered Pseudomonas putida

YS Ackermann, J de Witt, MP Mezzina, C Schroth… - Microbial Cell …, 2024 - Springer
Bio-upcycling of plastics is an emerging alternative process that focuses on extracting value
from a wide range of plastic waste streams. Such streams are typically too contaminated to …

Expanding Pseudomonas taiwanensis VLB120's acyl‐CoA portfolio: Propionate production in mineral salt medium

D Neves, D Meinen, TB Alter, LM Blank… - Microbial …, 2024 - Wiley Online Library
As one of the main precursors, acetyl‐CoA leads to the predominant production of even‐
chain products. From an industrial biotechnology perspective, extending the acyl‐CoA …

From oil to bioplastics, a dream come true?

MA Prieto - Journal of Bacteriology, 2007 - Am Soc Microbiol
Human overpopulation combined with the current lifestyle urges the rational, efficient, and
sustainable use of natural resources to produce environmentally friendly plastic materials …

Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli

K Tokuyama, S Ohno, K Yoshikawa, T Hirasawa… - Microbial cell …, 2014 - Springer
Abstract Background 3-hydroxypropionic acid (3HP) is an important chemical precursor for
the production of bioplastics. Microbial production of 3HP from glycerol has previously been …

Elevated production of 3-hydroxypropionic acid by metabolic engineering of the glycerol metabolism in Escherichia coli

WS Jung, JH Kang, HS Chu, IS Choi, KM Cho - Metabolic engineering, 2014 - Elsevier
Hydroxypropionic acid (3-HP) is a renewable-based platform chemical which may be used
to produce a wide range of chemicals including acrylic acid, 1, 3-propanediol, and …

High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii

VET Maervoet, SL De Maeseneire, FG Avci… - Microbial cell …, 2016 - Springer
Background Imbalance in cofactors causing the accumulation of intermediates in
biosynthesis pathways is a frequently occurring problem in metabolic engineering when …