Abstract The small Rho GTPase family of proteins, encompassing the three major G-protein
classes Rho, Rac and cell division control protein 42, are key mitogenic signaling molecules …

Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) …

Remarkable progress has been made in understanding effector molecules of small GTPase
Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho …

Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key
aspects of the actin cytoskeleton, but their role in proliferation and cancer initiation or …

The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …

Cancer-associated changes in cellular behavior, such as modified cell-cell contact,
increased migratory potential, and generation of cellular force, all require alteration of the …

Rho kinase (ROCK) proteins are Rho-GTPase activated serine/threonine kinases that
function as modulators of actin-myosin cytoskeletal dynamics via regulation of Lin11, Isl-1 & …

In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …