Protection afforded by quercetin against H2O2-induced apoptosis on PC12 cells via activating PI3K/Akt signal pathway

L Chen, L Sun, Z Liu, H Wang, C Xu - Journal of Receptors and …, 2016 - Taylor & Francis
Cell damage and apoptosis induced by oxidative stress have been involved in various
neurodegenerative diseases. This study aims to explore the neuro-protective effects of …

Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells

N Suematsu, M Hosoda, K Fujimori - Neuroscience letters, 2011 - Elsevier
Hydrogen peroxide (H2O2) is a major reactive oxygen species that has been implicated in
various neurodegenerative diseases. Quercetin, one of the plant flavonoids, has been …

Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1α

F Roshanzamir, R Yazdanparast - Neuroscience, 2014 - Elsevier
Evidence is emerging that reactive oxygen species (ROS)-induced oxidative stress has a
crucial role in the pathogenesis of neurodegenerative diseases. To find the effective …

Potent Effects of Flavonoid-Rich Extract from Rosa laevigata Michx Fruit against Hydrogen Peroxide-Induced Damage in PC12 Cells via Attenuation of Oxidative …

M Liu, Y Xu, X Han, C Liang, L Yin, L Xu, Y Qi, Y Zhao… - Molecules, 2014 - mdpi.com
Oxidative stress-induced neuronal death has an important role in the pathogenesis of
neurodegenerative disorders. The effects and mechanisms of action of the total flavonoids …

Lycopene protects human SH‑SY5Y neuroblastoma cells against hydrogen peroxide‑induced death via inhibition of oxidative stress and mitochondria‑associated …

C Feng, T Luo, S Zhang, K Liu… - Molecular …, 2016 - spandidos-publications.com
Oxidative stress, which is characterized by excessive production of reactive oxygen species
(ROS), is a common pathway that results in neuronal injury or death due to various types of …

Protective effect of quercetin against oxidative stress-induced cytotoxicity in rat pheochromocytoma (PC-12) cells

D Bao, J Wang, X Pang, H Liu - Molecules, 2017 - mdpi.com
Oxidative stress has been implicated in the pathogenesis of many kinds of
neurodegenerative disorders, particularly Parkinson's disease. Quercetin is a bioflavonoid …

Strategy to suppress oxidative damage-induced neurotoxicity in PC12 cells by curcumin: the role of ROS-mediated DNA damage and the MAPK and AKT pathways

X Fu, M Yang, M Cao, D Li, X Yang, J Sun… - Molecular …, 2016 - Springer
Oxidative damage plays a key role in causation and progression of neurodegenerative
diseases. Inhibition of oxidative stress represents one of the most effective ways in treating …

Flavonoid Baicalein Modulates H2O2-Induced Mitogen-Activated Protein Kinases Activation and Cell Death in SK-N-MC Cells

M Moslehi, A Meshkini, R Yazdanparast - Cellular and molecular …, 2012 - Springer
It is believed that ROS-induced oxidative stress triggers numerous signaling pathways which
are involved in neurodegenerative diseases, including Alzheimer's disease. To find the …

Quercetin inhibition of ROS-dependent and-independent apoptosis in rat glioma C6 cells

TJ Chen, JY Jeng, CW Lin, CY Wu, YC Chen - Toxicology, 2006 - Elsevier
In the present study, we investigated the protective mechanism of quercetin (QUE) and its
glycosides, rutin (RUT) and quercitrin (QUI), on reactive oxygen species (ROS)-dependent …

Neuroprotective Effect of Rosmarinus officinalis Extract on Human Dopaminergic Cell line, SH-SY5Y

SE Park, S Kim, K Sapkota, SJ Kim - Cellular and molecular neurobiology, 2010 - Springer
Abstract Hydrogen peroxide (H 2 O 2) is a major Reactive Oxygen Species (ROS), which
has been implicated in many neurodegenerative conditions including Parkinson's disease …