Somatic mutations have been studied extensively in the context of cancer. Recent studies
have demonstrated that high-throughput sequencing data can be used to detect somatic …

Normal tissues progressively acquire mutations. Some mutations are positively selected,
driving clonal expansions that may colonize the majority of a tissue by old age. In several …

The genome of multicellular organisms carries the hereditary information necessary for the
development of all organs and tissues and to maintain function in adulthood. To ensure the …

Background It has long been known that mutations are at the core of many diseases, most
notably cancer. Mutational analysis of tissues and fluids is useful for cancer and other …

Next generation sequencing (NGS) coupled with sophisticated bioinformatics tools yields an
unprecedented amount of information regarding tumor genetics, with the potential to reveal …

The somatic mutations in each cancer genome are caused by multiple mutational
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …

Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …

Background Seemingly normal tissues progressively become populated by mutant clones
over time. Most of these clones bear mutations in well-known cancer genes but only rarely …

Background Somatic mutations in healthy tissues contribute to aging, neurodegeneration,
and cancer initiation, yet they remain largely uncharacterized. Results To gain a better …

From conception to death, human cells accumulate somatic mutations in their genomes.
These mutations can contribute to the development of cancer and non-malignant diseases …