Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

Improved identification of cancer mutational processes | Nature Genetics Skip to main content
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Somatic mutations are DNA variants that occur after the fertilization of zygotes and
accumulate during the developmental and aging processes in the human lifespan. Somatic …

Next generation sequencing technologies (NGS) have been critical in characterizing the
genomic landscape and untangling the genetic heterogeneity of human cancer. Since its …

Cancer arises as a result of acquired changes in the DNA sequence of the genome of
somatic cells. A subset of the genetic changes, dubbed driver mutations, propels tumor …

Background The lifelong accumulation of somatic mutations underlies age-related
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …

A widely accepted paradigm in cancer research holds that the development of cancers is
rate limited by the occurrence of oncogenic mutations. In particular, the exponential rise in …

Recent advances in technological tools for massively parallel, high-throughput sequencing
of DNA have enabled the comprehensive characterization of somatic mutations in a large …

Highlights•New methods enable insights into mutation burden in normal tissues.•Mutation
burden rises with age, varying across cell types and species.•Insights into regulating …

Every cell in our body accumulates mutations throughout life, and sometimes an unfortunate
combination of mutations drives the initiation of cancer. A new study infers extraordinarily …