In recent years, the increasing awareness that somatic mutations and other genetic
aberrations drive human malignancies has led us within reach of personalized cancer …

INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …

Abstract COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer. sanger. ac.
uk) is the world's largest and most comprehensive resource for exploring the impact of …

Somatic mutations are accumulated in normal human tissues with aging and exposure to
carcinogens. If we can accurately count any passenger mutations in any single DNA …

Cancer is often driven by the accumulation of genetic alterations, including single nucleotide
variants, small insertions or deletions, gene fusions, copy-number variations, and large …

A root cause of cancer is the accumulation of defects in genes that play critical roles in
regulating cell proliferation, cellular differentiation, and cell death. The mutations in cancer …

High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer
detection by enabling the identification of mutant cancer molecules in minimally invasive …

Aging represents the major risk factor for the development of cancer and many other
diseases. Recent findings show that normal tissues become riddled with expanded clones …

Editorial summary Recent sequencing studies on healthy skin and esophagus have found
that, as we age, these tissues become colonized by mutant clones of cells carrying driver …

The introduction of next-generation sequencing technologies has dramatically impacted the
life sciences, perhaps most profoundly in the area of cancer genomics. Clinical applications …