Tumor sequencing projects have been initiated over the last decade with the promising goal
of identifying novel cancer genes and potential therapeutic targets. One of the unexpected …

Somatic mutations have long been implicated in aging and disease, but their impact on
fitness and function is difficult to assess. Here by analysing human cancer genomes we …

Background The identification and characterization of tumor suppressor genes has
enhanced our understanding of the biology of cancer and enabled the development of new …

Recurring sequences of genomic alterations occurring across patients can highlight
repeated evolutionary processes with significant implications for predicting cancer …

Cancer recapitulates Darwinian evolution. Mutations acquired during life that provide cells
with a growth or survival advantage will preferentially multiply to form a tumor. As a result of …

A vast effort has been invested in the identification of driver mutations of cancer. However,
recent studies and observations call into question whether the activating mutations or the …

Cancer is often called a disease of aging. There are numerous ways in which cancer
epidemiology and behaviour change with the age of the patient. The molecular bases for …

Cancer is sometimes depicted as a reversion to single cell behavior in cells adapted to live
in a multicellular assembly. If this is the case, one would expect that mutation in cancer …

High-throughput DNA sequencing is revolutionizing the study of cancer and enabling the
measurement of the somatic mutations that drive cancer development. However, the …

In a series of transforming initiatives such as the Cancer Genome Atlas, the genomic
landscapes for a variety of malignancies have been characterized in a reliable and robust …