Cancer profiling studies have had a profound impact on our understanding of the biology of
cancers in a number of ways, including providing insights into the biological heterogeneity of …

Postzygotic somatic mutations have been found associated with human disease, including
diseases other than cancer. Most information on somatic mutations has come from studying …

Following initial characterization of the reference human genome, initiatives have evolved
worldwide to identify genomic aberrations in cancer with the aim of deriving diagnostic …

Abstract COSMIC, the Catalogue Of Somatic Mutations In Cancer (https://cancer. sanger. ac.
uk) is the most detailed and comprehensive resource for exploring the effect of somatic …

The description and interpretation of genomic abnormalities in cancer cells have been at the
heart of cancer research for more than a century. With exhaustive sequencing of cancer …

The genome of each cell in the human body is constantly under assault from a plethora of
exogenous and endogenous processes that can damage DNA. If not successfully repaired …

Although oncogenic mutations have been found in nondiseased, proliferative nonneural
tissues, their prevalence in the human brain is unknown. Targeted sequencing of genes …

Successful treatment decisions in cancer depend on the accurate assessment of patient risk.
To improve our understanding of the molecular alterations that underlie deadly …

In recent years it has been shown that silent mutations, in and out of the coding region, can
affect gene expression and may be related to tumorigenesis and cancer cell fitness …

Background In the past decade, systematic and comprehensive analyses of cancer
genomes have identified cancer driver genes and revealed unprecedented insight into the …