Early intervention with a multi-ingredient dietary supplement improves mood and spatial memory in a triple transgenic mouse model of Alzheimer's disease

CP Hutton, JA Lemon, B Sakic… - Journal of …, 2018 - content.iospress.com
The increasing global burden of Alzheimer's disease (AD) and failure of conventional
treatments to stop neurodegeneration necessitates an alternative approach. Evidence of …

[HTML][HTML] Whole-food diet worsened cognitive dysfunction in an Alzheimer's disease mouse model

MD Parrott, G Winocur, RP Bazinet, DWL Ma… - Neurobiology of …, 2015 - Elsevier
Food combinations have been associated with lower incidence of Alzheimer's disease. We
hypothesized that a combination whole-food diet containing freeze-dried fish, vegetables …

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

VKM Halagappa, Z Guo, M Pearson, Y Matsuoka… - Neurobiology of …, 2007 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
decline in cognitive function associated with the neuropathological hallmarks amyloid β …

Broad-based nutritional supplementation in 3xTg mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer's disease intervention

AB Wolf, BB Braden, H Bimonte-Nelson… - Journal of …, 2012 - content.iospress.com
Nutrition has been highlighted as a potential factor in Alzheimer's disease (AD) risk and
decline and has been investigated as a therapeutic target. Broad-based combination diet …

[HTML][HTML] Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer's …

Z Bowers, P Maiti, A Bourcier, J Morse, K Jenrow… - Brain …, 2021 - ncbi.nlm.nih.gov
Combined treatments using polyphenols and omega fatty acids provide several therapeutic
benefits for a variety of age-related disorders, including Alzheimer's disease (AD) …

[HTML][HTML] High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

EM Knight, IVA Martins, S Gümüsgöz, SM Allan… - Neurobiology of …, 2014 - Elsevier
Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …

[HTML][HTML] Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease

LC Graham, JM Harder, I Soto, WN De Vries… - Scientific reports, 2016 - nature.com
Studies have assessed individual components of a western diet, but no study has assessed
the long-term, cumulative effects of a western diet on aging and Alzheimer's disease (AD) …

[HTML][HTML] Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease

A Parachikova, KN Green, C Hendrix, FM LaFerla - PloS one, 2010 - journals.plos.org
Background Dietary supplements have been extensively studied for their beneficial effects
on cognition and AD neuropathology. The current study examines the effect of a medical …

[HTML][HTML] A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease

A Attar, T Liu, WTC Chan, J Hayes, M Nejad, KC Lei… - PloS one, 2013 - journals.plos.org
Alzheimer's disease is a progressive neurodegenerative disease that manifests as memory
loss, cognitive dysfunction, and dementia. Animal models of Alzheimer's disease have been …

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

Y García-Mesa, L Giménez-Llort, LC López… - Neurobiology of …, 2012 - Elsevier
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no
specific treatment at present. Several healthy lifestyle options and over-the-counter drugs …