Neurotoxin-based models of Parkinson's disease

J Bové, C Perier - Neuroscience, 2012 - Elsevier
Animal experimentation in the Parkinson's disease (PD) field is a classic example of how the
use of animal models to study diseases can have a significant impact on human health …

Neurotoxin-induced animal models of Parkinson disease: pathogenic mechanism and assessment

XS Zeng, WS Geng, JJ Jia - ASN neuro, 2018 - journals.sagepub.com
Parkinson disease (PD) is the second most common neurodegenerative movement
disorder. Pharmacological animal models are invaluable tools to study the pathological …

Animal models of Parkinson's disease in rodents induced by toxins: an update

EC Hirsch, G Höglinger, E Rousselet, T Breidert… - Advances in Research …, 2003 - Springer
The development of animal models of Parkinson's disease is of great importance in order to
test substitutive or neuroprotective strategies for Parkinson's disease. Such models should …

[HTML][HTML] Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP

A Schober - Cell and tissue research, 2004 - Springer
Neurological disorders in humans can be modeled in animals using standardized
procedures that recreate specific pathogenic events and their behavioral outcomes. The …

Chemically induced models of Parkinson's disease

T Thirugnanam, K Santhakumar - … and Physiology Part C: Toxicology & …, 2022 - Elsevier
Environmental toxins are harmful substances detrimental to humans. Constant exposure to
these fatal neurotoxins can cause various neurodegenerative disorders. Although …

Toxin-induced models of Parkinson's disease

J Bové, D Prou, C Perier, S Przedborski - NeuroRx, 2005 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disease that appears essentially
as a sporadic condition. It results mainly from the death of dopaminergic neurons in the …

[HTML][HTML] Historical perspective: models of Parkinson's disease

SJ Chia, EK Tan, YX Chao - International journal of molecular sciences, 2020 - mdpi.com
Parkinson's disease (PD) is the most common movement disorder with motor and nonmotor
signs. The current therapeutic regimen for PD is mainly symptomatic as the etio …

Dynamic changes in the nigrostriatal pathway in the MPTP mouse model of Parkinson's disease

D Huang, J Xu, J Wang, J Tong, X Bai, H Li… - Parkinson's …, 2017 - Wiley Online Library
The characteristic brain pathology and motor and nonmotor symptoms of Parkinson's
disease (PD) are well established. However, the details regarding the causes of the disease …

Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and α-synuclein-deleted mice

D Alvarez-Fischer, C Henze, C Strenzke… - Experimental …, 2008 - Elsevier
Genetically modified mice models are increasingly used to study the pathophysiology of
Parkinson's disease (PD), particularly in conditions where they are subjected to toxins …

Neurotoxic in vivo models of Parkinson's disease: recent advances

JR Cannon, JT Greenamyre - Progress in brain research, 2010 - Elsevier
Animal models have been invaluable to Parkinson's disease (PD) research. Of these,
neurotoxin models have historically been the most widely utilized. The goal of this chapter is …