Tissue-specific endothelial cells are more than simply a barrier lining capillaries and are
proved to be capable of remarkable plasticity to become active collagen matrix-producing …

Because of the prevalence of viral hepatitis and nonalcoholic fatty liver disease (NAFLD),
liver fibrosis has become a very common disease in Asia and elsewhere in the world …

Chronic liver diseases are attributed to liver injury. Development of fibrosis from chronic liver
diseases is a dynamic process that involves multiple molecular and cellular processes. As …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. It is a critical pre‑stage condition of severe hepatopathy, characterized by excessive …

Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of
an organized basement membrane not only precedes fibrosis, but is also permissive for …

Liver sinusoidal endothelial cells (LSECs) possess fenestrae, which are key for the
exchange between blood and hepatocytes. Alterations in their number or diameter have …

Fibrosis is one of the hallmarks of chronic liver disease and is associated with aberrant
wound healing. Changes in the composition of the liver microenvironment during fibrosis …

Liver fibrosis is a wound‐healing response to chronic liver injury such as
alcoholic/nonalcoholic fatty liver disease and viral hepatitis with no FDA‐approved …

Liver sinusoidal endothelial cells have a gatekeeper function in liver homeostasis by
permitting substrates from the bloodstream into the space of Disse and regulating hepatic …

Normal liver sinusoidal endothelial cells (LSECs) promote quiescence of hepatic stellate
cells (HSCs). Prior to fibrosis, LSECs undergo capillarization, which is permissive for HSC …