[HTML][HTML] Capillarized liver sinusoidal endothelial cells undergo partial endothelial-mesenchymal transition to actively deposit sinusoidal ECM in liver fibrosis
B Ruan, JL Duan, H Xu, KS Tao, H Han… - Frontiers in Cell and …, 2021 - frontiersin.org
Tissue-specific endothelial cells are more than simply a barrier lining capillaries and are
proved to be capable of remarkable plasticity to become active collagen matrix-producing …
proved to be capable of remarkable plasticity to become active collagen matrix-producing …
Key role of liver sinusoidal endothelial cells in liver fibrosis
M Xu, X Wang, Y Zou, Y Zhong - Bioscience trends, 2017 - jstage.jst.go.jp
Because of the prevalence of viral hepatitis and nonalcoholic fatty liver disease (NAFLD),
liver fibrosis has become a very common disease in Asia and elsewhere in the world …
liver fibrosis has become a very common disease in Asia and elsewhere in the world …
Liver sinusoidal endothelial cells are implicated in multiple fibrotic mechanisms
H Ma, X Liu, M Zhang, J Niu - Molecular Biology Reports, 2021 - Springer
Chronic liver diseases are attributed to liver injury. Development of fibrosis from chronic liver
diseases is a dynamic process that involves multiple molecular and cellular processes. As …
diseases is a dynamic process that involves multiple molecular and cellular processes. As …
[HTML][HTML] Liver sinusoidal endothelial cells as potential drivers of liver fibrosis
J Gao, B Zuo, Y He - Molecular Medicine Reports, 2024 - build.spandidos-publications.com
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. It is a critical pre‑stage condition of severe hepatopathy, characterized by excessive …
health. It is a critical pre‑stage condition of severe hepatopathy, characterized by excessive …
Liver sinusoidal endothelial cells in hepatic fibrosis
LD DeLeve - Hepatology, 2015 - journals.lww.com
Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of
an organized basement membrane not only precedes fibrosis, but is also permissive for …
an organized basement membrane not only precedes fibrosis, but is also permissive for …
[PDF][PDF] Actin depolymerization in dedifferentiated liver sinusoidal endothelial cells promotes fenestrae re‐formation
J Di Martino, P Mascalchi, P Legros… - Hepatology …, 2019 - Wiley Online Library
Liver sinusoidal endothelial cells (LSECs) possess fenestrae, which are key for the
exchange between blood and hepatocytes. Alterations in their number or diameter have …
exchange between blood and hepatocytes. Alterations in their number or diameter have …
[HTML][HTML] Engineered matrix microenvironments reveal the heterogeneity of liver sinusoidal endothelial cell phenotypic responses
A Brougham-Cook, HRC Kimmel, CP Monckton… - APL …, 2022 - pubs.aip.org
Fibrosis is one of the hallmarks of chronic liver disease and is associated with aberrant
wound healing. Changes in the composition of the liver microenvironment during fibrosis …
wound healing. Changes in the composition of the liver microenvironment during fibrosis …
SECs (sinusoidal endothelial cells), liver microenvironment, and fibrosis
V Natarajan, EN Harris… - BioMed research …, 2017 - Wiley Online Library
Liver fibrosis is a wound‐healing response to chronic liver injury such as
alcoholic/nonalcoholic fatty liver disease and viral hepatitis with no FDA‐approved …
alcoholic/nonalcoholic fatty liver disease and viral hepatitis with no FDA‐approved …
[HTML][HTML] Gene signatures detect damaged liver sinusoidal endothelial cells in chronic liver diseases
S Verhulst, EA van Os, V De Smet, N Eysackers… - Frontiers in …, 2021 - frontiersin.org
Liver sinusoidal endothelial cells have a gatekeeper function in liver homeostasis by
permitting substrates from the bloodstream into the space of Disse and regulating hepatic …
permitting substrates from the bloodstream into the space of Disse and regulating hepatic …
[PDF][PDF] Incomplete differentiation of engrafted bone marrow endothelial progenitor cells initiates hepatic fibrosis in the rat
AC Maretti‐Mira, X Wang, L Wang, LD DeLeve - Hepatology, 2019 - Wiley Online Library
Normal liver sinusoidal endothelial cells (LSECs) promote quiescence of hepatic stellate
cells (HSCs). Prior to fibrosis, LSECs undergo capillarization, which is permissive for HSC …
cells (HSCs). Prior to fibrosis, LSECs undergo capillarization, which is permissive for HSC …