The aim of the present study was to compare different diets used to induce obesity in a head-
to-head manner with a focus on insulin resistance and vascular dysfunction. Male C57BL/6J …

Aim Nutrition contributes to increased adiposity, but it remains to be determined whether
high fat rather than Western diet exacerbates the development of obesity and other …

Background Animal models of diet‐induced obesity (DIO) are commonly used in medical
research for mimicking human diseases. There is no universal animal model, and careful …

Vascular endothelial dysfunction has been demonstrated in obesity, but the molecular basis
for this link has not been clarified. We examined the role of free fatty acids (FFA) on vascular …

Obesity is involved in several cardiovascular diseases including coronary artery disease
and endothelial dysfunction. Endothelial Endothelium vasodilator and vasoconstrictor …

Objective We investigated the effects of high-fat diet-induced obesity on vascular
proinflammatory factors and oxidative stress on endothelium-dependent relaxation of the …

Background The hypothesis of this study is that long-term high-fat diets (HFD) induce
perivascular adipose tissue (PVAT) dysfunction characterized by a redox imbalance, which …

Impaired arterial vasorelaxation, due primarily to endothelial dysfunction, is associated with
obesity. To clarify the relationship with insulin resistance and other metabolic disturbances …

Objective—The present study was conducted to investigate the contribution of perivascular
adipose tissue (PVAT) to vascular dysfunction in a mouse model of diet-induced obesity …

Background The objective of this study was to determine the effect of diet‐induced obesity
(DIO) on microvascular and neural function. Methods Rats were fed a standard or high fat …