In inflammatory bowel disease (IBD), chronic inflammation in the gastrointestinal tract can
lead to tissue damage and remodelling, which can ultimately result in fibrosis. Prolonged …

Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease
[IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn's …

Fibrosis is a chronic and progressive process characterized by an excessive accumulation
of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue …

Introduction: Extracellular matrix (ECM) remodeling of the intestinal tissue is important in
inflammatory bowel disease (IBD) due to the extensive mucosal remodeling. There are still …

Intestinal inflammatory fibrosis is a severe consequence of inflammatory bowel diseases
(IBD). There is currently no cure for the treatment of intestinal fibrosis in IBD. Although …

Background: Intestinal fibrosis in Crohn's disease (CD) is considered to be irreversible and
induces persistent luminal narrowing and strictures. In the past decades, substantial …

The rapidly increasing incidence of inflammatory bowel disease (IBD) in South America,
eastern Europe, Asia, and Africa has resulted in a global public health challenge. Intestinal …

The intestinal wall represents an interactive network regulated by the intestinal epithelium,
extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological …

Intestinal fibrosis associated stricture is a common complication of inflammatory bowel
disease usually requiring endoscopic or surgical intervention. Effective anti-fibrotic agents …

The intestinal epithelium has a strategic position as a protective physical barrier to luminal
microbiota and actively contributes to the mucosal immune system. This barrier is mainly …