Endothelins including its most abundant isoform, endothelin-1 (ET-1), are peptides acting as
vasoconstrictors when binding to ET A and ET B receptors, and, in addition to their distinct …

Cardiovascular disease is a major contributor to global morbidity and mortality and is the
common end point of many chronic diseases. The endothelins comprise three structurally …

The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin
peptide family, which includes ET-2, ET-3, and ET-4. It exerts various biological effects …

Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-
2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted …

The incidence of chronic kidney disease (CKD) is increasing worldwide. Cardiovascular
disease (CVD) is strongly associated with CKD and constitutes one of its major causes of …

The endothelins comprise a family of three isopeptides ET-1, ET-2 and ET-3, whereby ET-1
appears to be the most relevant in humans. They act in a paracrine manner on ET A and ET …

Endothelin-1 (ET-1), the predominant isoform of the endothelin peptide family, has potent
vasoconstrictor, mitogenic, pro-inflammatory and antinatriuretic properties which have been …

Endothelins (ET-1, ET-2 and ET-3) are a family of 21 amino acid peptides produced by
endothelial cells. They are thought to regulate the local vasomotor tone with endothelium …

Endothelins are powerful vasoconstrictor peptides that also play numerous other roles. The
endothelin (ET) family consists of three peptides produced by a variety of tissues. Endothelin …

Abstract Endothelin (ET)‐1 is a potent vasoconstrictor peptide with pro‐inflammatory,
mitogenic, and pro‐fibrotic properties that is closely involved in both normal renal physiology …