Cancer progression and the invisible phase of metastatic colonization
CA Klein - Nature Reviews Cancer, 2020 - nature.com
Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …
Rethinking the metastatic cascade as a therapeutic target
LA Mina, GW Sledge Jr - Nature reviews Clinical oncology, 2011 - nature.com
Metastasis is the leading cause of cancer death. The metastatic cascade is a complex yet
inefficient process that we have only begun to understand in recent years. Several of the …
inefficient process that we have only begun to understand in recent years. Several of the …
Metastasis: recent discoveries and novel treatment strategies
SA Eccles, DR Welch - The Lancet, 2007 - thelancet.com
Most cancer deaths are due to the development of metastases, hence the most important
improvements in morbidity and mortality will result from prevention (or elimination) of such …
improvements in morbidity and mortality will result from prevention (or elimination) of such …
The dormancy dilemma: quiescence versus balanced proliferation
Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of
morbidity and mortality from most solid tumors. Even more daunting is that many of these …
morbidity and mortality from most solid tumors. Even more daunting is that many of these …
Metastatic progression is associated with dynamic changes in the local microenvironment
NM Aiello, DL Bajor, RJ Norgard, A Sahmoud… - Nature …, 2016 - nature.com
Most cancer-associated deaths result from metastasis. However, it remains unknown
whether the size, microenvironment or other features of a metastatic lesion dictate its …
whether the size, microenvironment or other features of a metastatic lesion dictate its …
Mechanisms of metastasis
Metastatic disease is the culmination of cancer and its most common life-threatening
manifestation. The highly complex process by which cancer cells disseminate to and …
manifestation. The highly complex process by which cancer cells disseminate to and …
Dissecting the metastatic cascade
K Pantel, RH Brakenhoff - Nature reviews cancer, 2004 - nature.com
Despite recent progress in gene-expression profiling studies, the biology underlying the
various patterns of metastasis that are observed in different tumour types remains unclear …
various patterns of metastasis that are observed in different tumour types remains unclear …
Do all roads lead to Rome? Routes to metastasis development
JP Sleeman, I Nazarenko… - International Journal of …, 2011 - Wiley Online Library
Metastasis, the life‐threatening aspect of cancer, is a systemic disease process.
Considerable progress has been made in recent years regarding how tumor cells circulating …
Considerable progress has been made in recent years regarding how tumor cells circulating …
Metastasis prevention by targeting the dormant niche
CM Ghajar - Nature Reviews Cancer, 2015 - nature.com
Despite considerable advancements that shattered previously held dogmas about the
metastatic cascade, the evolution of therapies to treat metastatic disease has not kept up. In …
metastatic cascade, the evolution of therapies to treat metastatic disease has not kept up. In …
Cancer metastasis: a reappraisal of its underlying mechanisms and their relevance to treatment
N Riggi, M Aguet, I Stamenkovic - Annual Review of Pathology …, 2018 - annualreviews.org
Metastases are responsible for the vast majority of cancer-related deaths, but, despite
intense efforts to understand their underlying mechanisms with the goal of uncovering …
intense efforts to understand their underlying mechanisms with the goal of uncovering …