Single-cell transcriptomics in the Drosophila visual system: Advances and perspectives on cell identity regulation, connectivity, and neuronal diversity evolution

F Simon, N Konstantinides - Developmental biology, 2021 - Elsevier
The Drosophila visual system supports complex behaviors and shares many of its
anatomical and molecular features with the vertebrate brain. Yet, it contains a much more …

Gene regulatory networks during the development of the Drosophila visual system

YC Chen, C Desplan - Current topics in developmental biology, 2020 - Elsevier
The Drosophila visual system integrates input from 800 ommatidia and extracts different
features in stereotypically connected optic ganglia. The development of the Drosophila …

Phenotypic convergence: distinct transcription factors regulate common terminal features

N Konstantinides, K Kapuralin, C Fadil, L Barboza… - Cell, 2018 - cell.com
Transcription factors regulate the molecular, morphological, and physiological
characteristics of neurons and generate their impressive cell-type diversity. To gain insight …

Generation and Evolution of Neural Cell Types and Circuits: Insights from the Drosophila Visual System

M Perry, N Konstantinides… - Annual review of …, 2017 - annualreviews.org
The Drosophila visual system has become a premier model for probing how neural diversity
is generated during development. Recent work has provided deeper insight into the …

[HTML][HTML] Transcriptional programs of circuit assembly in the Drosophila visual system

YZ Kurmangaliyev, J Yoo, J Valdes-Aleman… - Neuron, 2020 - cell.com
Precise patterns of synaptic connections between neurons are encoded in their genetic
programs. Here, we use single-cell RNA sequencing to profile neuronal transcriptomes at …

From the eye to the brain: development of the Drosophila visual system

N Nériec, C Desplan - Current topics in developmental biology, 2016 - Elsevier
How stem cells produce the huge diversity of neurons that form the visual system, and how
these cells are assembled in neural circuits are a critical question in developmental …

A Challenge of Numbers and Diversity: Neurogenesis in the Drosophila Optic Lobe

H Apitz, I Salecker - Journal of neurogenetics, 2014 - Taylor & Francis
The brain areas that endow insects with the ability to see consist of remarkably complex
neural circuits. Reiterated arrays of many diverse neuron subtypes are assembled into …

A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages

M Corrales, BT Cocanougher, AB Kohn… - Neural …, 2022 - Springer
Molecular profiles of neurons influence neural development and function but bridging the
gap between genes, circuits, and behavior has been very difficult. Here we used single cell …

Single cell transcriptome atlas of the Drosophila larval brain

C Brunet Avalos, GL Maier, R Bruggmann… - Elife, 2019 - elifesciences.org
Cell diversity of the brain and how it is affected by starvation, remains largely unknown.
Here, we introduce a single cell transcriptome atlas of the entire Drosophila first instar larval …

A Drosophila glial cell atlas reveals a mismatch between transcriptional and morphological diversity

I Lago-Baldaia, M Cooper, A Seroka, C Trivedi… - PLoS …, 2023 - journals.plos.org
Morphology is a defining feature of neuronal identity. Like neurons, glia display diverse
morphologies, both across and within glial classes, but are also known to be …