Single-cell transcriptomics in the Drosophila visual system: Advances and perspectives on cell identity regulation, connectivity, and neuronal diversity evolution
F Simon, N Konstantinides - Developmental biology, 2021 - Elsevier
The Drosophila visual system supports complex behaviors and shares many of its
anatomical and molecular features with the vertebrate brain. Yet, it contains a much more …
anatomical and molecular features with the vertebrate brain. Yet, it contains a much more …
Gene regulatory networks during the development of the Drosophila visual system
The Drosophila visual system integrates input from 800 ommatidia and extracts different
features in stereotypically connected optic ganglia. The development of the Drosophila …
features in stereotypically connected optic ganglia. The development of the Drosophila …
Phenotypic convergence: distinct transcription factors regulate common terminal features
Transcription factors regulate the molecular, morphological, and physiological
characteristics of neurons and generate their impressive cell-type diversity. To gain insight …
characteristics of neurons and generate their impressive cell-type diversity. To gain insight …
Generation and Evolution of Neural Cell Types and Circuits: Insights from the Drosophila Visual System
M Perry, N Konstantinides… - Annual review of …, 2017 - annualreviews.org
The Drosophila visual system has become a premier model for probing how neural diversity
is generated during development. Recent work has provided deeper insight into the …
is generated during development. Recent work has provided deeper insight into the …
[HTML][HTML] Transcriptional programs of circuit assembly in the Drosophila visual system
Precise patterns of synaptic connections between neurons are encoded in their genetic
programs. Here, we use single-cell RNA sequencing to profile neuronal transcriptomes at …
programs. Here, we use single-cell RNA sequencing to profile neuronal transcriptomes at …
From the eye to the brain: development of the Drosophila visual system
N Nériec, C Desplan - Current topics in developmental biology, 2016 - Elsevier
How stem cells produce the huge diversity of neurons that form the visual system, and how
these cells are assembled in neural circuits are a critical question in developmental …
these cells are assembled in neural circuits are a critical question in developmental …
A Challenge of Numbers and Diversity: Neurogenesis in the Drosophila Optic Lobe
H Apitz, I Salecker - Journal of neurogenetics, 2014 - Taylor & Francis
The brain areas that endow insects with the ability to see consist of remarkably complex
neural circuits. Reiterated arrays of many diverse neuron subtypes are assembled into …
neural circuits. Reiterated arrays of many diverse neuron subtypes are assembled into …
A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages
M Corrales, BT Cocanougher, AB Kohn… - Neural …, 2022 - Springer
Molecular profiles of neurons influence neural development and function but bridging the
gap between genes, circuits, and behavior has been very difficult. Here we used single cell …
gap between genes, circuits, and behavior has been very difficult. Here we used single cell …
Single cell transcriptome atlas of the Drosophila larval brain
C Brunet Avalos, GL Maier, R Bruggmann… - Elife, 2019 - elifesciences.org
Cell diversity of the brain and how it is affected by starvation, remains largely unknown.
Here, we introduce a single cell transcriptome atlas of the entire Drosophila first instar larval …
Here, we introduce a single cell transcriptome atlas of the entire Drosophila first instar larval …
A Drosophila glial cell atlas reveals a mismatch between transcriptional and morphological diversity
Morphology is a defining feature of neuronal identity. Like neurons, glia display diverse
morphologies, both across and within glial classes, but are also known to be …
morphologies, both across and within glial classes, but are also known to be …