Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia

M Huang, JC Watso, LN Belval… - American Journal …, 2022 - journals.physiology.org
Hemorrhage is a leading cause of battlefield and civilian trauma deaths. Several pain
medications, including fentanyl, are recommended for use in the prehospital (ie, field setting) …

Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow

JC Watso, LN Belval, FA Cimino 3rd… - American Journal …, 2022 - journals.physiology.org
Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths. Low-
dose (ie, an analgesic dose) morphine is recommended for use in the prehospital (ie, field) …

Comparing the effects of low-dose ketamine, fentanyl, and morphine on hemorrhagic tolerance and analgesia in humans

JC Watso, M Huang, JM Hendrix… - Prehospital …, 2023 - Taylor & Francis
Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths.
Ketamine, fentanyl, and morphine are recommended analgesics for use in the prehospital …

Low-dose fentanyl reduces pain perception, muscle sympathetic nerve activity responses, and blood pressure responses during the cold pressor test

JC Watso, M Huang, LN Belval… - American Journal …, 2022 - journals.physiology.org
Our knowledge about how low-dose (analgesic) fentanyl affects autonomic cardiovascular
regulation is primarily limited to animal experiments. Notably, it is unknown if low-dose …

Low‐dose ketamine affects blood pressure, but not muscle sympathetic nerve activity, during progressive central hypovolemia without altering tolerance

M Huang, JC Watso, G Moralez… - The Journal of …, 2020 - Wiley Online Library
Key points Haemorrhage is the leading cause of battlefield and civilian trauma deaths.
Given that a haemorrhagic injury on the battlefield is almost always associated with pain, it is …

Comparison of muscle sympathetic responses to hemorrhage and lower body negative pressure in humans

RF Rea, M Hamdan, MP Clary… - Journal of Applied …, 1991 - journals.physiology.org
We compared changes in muscle sympathetic nerve activity (SNA) during graded lower
body negative pressure (LBNP) and 450 ml of hemorrhage in nine healthy volunteers …

Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage

L Xiang, AS Calderon, HG Klemcke… - Journal of Trauma …, 2020 - journals.lww.com
BACKGROUND Peripheral vasoconstriction is the most critical compensating mechanism
following hemorrhage to maintain blood pressure. On the battlefield, ketamine rather than …

Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals

JC Schadt, J Ludbrook - American Journal of Physiology …, 1991 - journals.physiology.org
In conscious mammals including humans, the neurohumoral and hemodynamic responses
to progressive acute hypovolemia have two distinct phases. There is an initial arterial …

Sympathetic activity during graded central hypovolemia in hypoxemic humans

LB Rowell, DR Seals - American Journal of Physiology …, 1990 - journals.physiology.org
To determine how hypoxemia (Hx) might alter muscle sympathetic nerve activity (MSNA)(
microneurography, peroneal nerve), norepinephrine (NE) levels, and vasoconstriction …

Relation of plasma norepinephrine and sympathetic traffic during hypotension in humans

RF Rea, DL Eckberg, JM Fritsch… - American Journal of …, 1990 - journals.physiology.org
We compared changes in antecubital venous plasma levels of norepinephrine (NE) and
peroneal nerve muscle sympathetic activity (MSA) during and after nitroprusside (NP) …