Colorectal cancer (CRC) is a prevalent and aggressive malignancy with high mortality rates
and significant risks to human well-being. Population-wide screening for tumor suppressor …

The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal
tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal …

Pancreatic cancer is a deadly malignancy with limited treatment options. NLRX1 is a unique,
understudied member of the Nod-like Receptor (NLR) family of pattern recognition receptors …

Chronic inflammation in tumor microenvironment plays an important role at different stages
of tumor development. The specific mechanisms of the association and its role in providing a …

Nucleotide-binding domain, leucine-rich-repeat–containing proteins (NLRs) are intracellular
innate immune sensors of pathogen-associated and damage-associated molecular patterns …

Background: NOD-like receptor pyrin domain-3 (NLRP3) inflammasome activation is a
double-edged sword in tumorigenesis. Whether NLRP3 is involved in the progression and …

Background Gastrointestinal (GI) cancer is affecting millions of people globally, leading to
high incidence and mortality rates and a heavy economic burden. Nucleotide-binding …

An increased level of proinflammatory cytokines, including TNF-α in tumor microenvironment
regulates the bioenergetic capacity, immune evasion and survival of cancer cells. Emerging …

Nucleotide-binding domain and leucine-rich-repeat-containing family member X1 (NLRX1),
located in mitochondria, can recognize cytoplasmic pattern recognition receptors and is …

NLRC3 inhibits mTOR in colorectal cancer | Nature Reviews Immunology Skip to main content
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