This issue of the journal Metabolism celebrates the 20 years since the discovery of the
prototypical adipose tissue secreted hormone leptin [1],[2],[3],[4],[5],[6],[7],[8],[9]. Leptin has …

Leptin is an adipokine and its name derives from the Greek word lepto 2 (leptos), which
means thin. Since its initial discovery in 1994, important advances have been made, and …

Leptin has been shown to have a wide repertoire of peripheral effects, some of which are
mediated through the central nervous system and others that are induced through a direct …

Twenty years after its discovery, recombinant human leptin has been approved by the Food
and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a …

Leptin has emerged over the past decade as a key hormone in not only the regulation of
food intake and energy expenditure but also in the regulation of neuroendocrine and …

THE DISCOVERY of leptin in 1994 has provided a major new piece in the puzzle of obesity.
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Leptin, a peptide secreted by the white adipose tissue, circulates to the central nervous
system and signals the status of body energy stores, regulating feeding behavior and energy …

Despite significant reductions in the consumption of dietary fat, the prevalence of obesity is
steadily rising in western civilization. Of particular concern is the recent epidemic of …

Leptin is an adipose tissue hormone that functions as an afferent signal in a negative
feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine …