Background It is clinically important to know who are likely to respond more or less to
antidepressants. However, meaningful effect modifiers (variables associated with differential …

Objective The role of baseline severity as effect modifier in various psychiatric disorders is a
topic of controversy and of clinical import. This study aims to examine whether baseline …

Several often-cited meta-analyses have reported that the efficacy of antidepressant
medications depends on the severity of depression. They found that drug–placebo …

Background The observation that some patients appear to respond better to antidepressants
for depression than others encourages the assumption that the effect of antidepressants …

Importance Antidepressants are commonly used to treat major depressive disorder (MDD).
Antidepressant outcomes can vary based on individual differences; however, it is unclear …

Context Antidepressant medications represent the best established treatment for major
depressive disorder, but there is little evidence that they have a specific pharmacological …

Objective To determine the relative variability and magnitude of symptomatic improvement in
antidepressant-treated individuals compared to placebo-treated individuals, and to …

Although increased pre-treatment severity of depressive symptoms is thought to suggest
better outcome with tricyclic antidepressants, it is unclear if such a pattern exists among …

Background Meta-analyses of antidepressant medications have reported only modest
benefits over placebo treatment, and when unpublished trial data are included, the benefit …

Importance Antidepressants are commonly used worldwide to treat major depressive
disorder. Symptomatic response to antidepressants can vary depending on differences …