Spontaneous and induced nontransgenic animal models of AD: modeling AD using combinatorial approach

A Kaushal, WY Wani, R Anand… - American Journal of …, 2013 - journals.sagepub.com
Alzheimer's disease (AD), the most common neurodegenerative and dementing disorder, is
characterized by extracellular amyloid deposition, intracellular neurofibrillary tangle …

Selecting a mouse model of Alzheimer's disease

J Chin - … Disease and Frontotemporal Dementia: Methods and …, 2011 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease and cause of
dementia. Significant strides toward understanding and developing therapies for AD have …

Modeling Alzheimer's disease in transgenic rats

S Do Carmo, AC Cuello - Molecular neurodegeneration, 2013 - Springer
Alzheimer's disease (AD) is the most common form of dementia. At the diagnostic stage, the
AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular …

Modeling Alzheimer's disease with non-transgenic rat models

L Lecanu, V Papadopoulos - Alzheimer's research & therapy, 2013 - Springer
Abstract Alzheimer's disease (AD), for which there is no cure, is the most common form of
dementia in the elderly. Despite tremendous efforts by the scientific community, the AD drug …

Animal models of Alzheimer's disease: preclinical insights and challenges

QQ Xu, W Yang, M Zhong, ZX Lin, NE Gray… - Acta Materia …, 2023 - scienceopen.com
Alzheimer's disease (AD), an irreversible neurodegenerative disease that progressively
impairs memory and cognitive judgment, severely affects the quality of life and imposes a …

Alzheimer's disease: experimental models and reality

E Drummond, T Wisniewski - Acta neuropathologica, 2017 - Springer
Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

[HTML][HTML] Experimentally induced animal models for cognitive dysfunction and Alzheimer's disease

D Rapaka, PC Adiukwu, VR Bitra - MethodsX, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised
pathologically by the presence of extracellular amyloid plaques and the intracellular …

[HTML][HTML] Animal models of Alzheimer's disease

G Casadesus, G Arendash, F Laferla… - International journal of …, 2010 - ncbi.nlm.nih.gov
The necessity for a deeper understanding of neurological diseases such as Alzheimer's
disease (AD) that increase in frequency as a function of age has become of paramount …

The usefulness and challenges of transgenic mouse models in the study of Alzheimer's disease

DM Wilcock - CNS & Neurological Disorders-Drug Targets …, 2010 - ingentaconnect.com
Alzheimer's disease is a progressive, neurodegenerative disorder characterized by a
devastating cognitive decline. The disease is identified pathologically by amyloid plaques …

Animal and cellular models of Alzheimer's disease: Progress, promise, and future approaches

L Trujillo-Estrada, E Sanchez-Mejias… - The …, 2022 - journals.sagepub.com
Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45
million people worldwide. Transgenic mouse models have made remarkable contributions …