Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in
the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate …

Abstract Objective Canonical Wnt/β-catenin signaling is a well-studied endogenous
regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and …

An inability of adipose tissue to expand consequent to exhausted capacity to recruit new
adipocytes might underlie the association between obesity and insulin resistance …

Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance in
obese individuals. Cell culture studies and gain-of-function mouse models suggest that …

Adipose tissues provide circulating nutrients and hormones. We present in vivo mouse
studies highlighting roles for Wnt signals in both aspects of metabolism. β-catenin activation …

The canonical Wnt signaling pathway is ubiquitous throughout the body and influences a
diverse array of physiological processes. Following the initial discovery of the Wnt signaling …

Adipocyte differentiation consists of a complex series of events in which scores of cellular
and extracellular factors interact to transform a fibroblast-like preadipocyte into a mature …

Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and
reside in various tissues, including bone marrow and adipose tissue. The differentiation …

At the cellular level, the biological processes of cell proliferation, growth arrest,
differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic …

Wnt10b is an established regulator of mesenchymal stem cell (MSC) fate that inhibits
adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo …