Oxidative stress has been implicated in aging and many human diseases, notably
neurodegenerative disorders and various cancers. The reactive oxygen species that are …

Cell homeostasis and regulation of metabolic pathways are ensured by synthesis, proper
folding and efficient degradation of a vast amount of proteins. Ubiquitin-proteasome system …

The ubiquitin proteasome pathway plays a critical role in regulating many processes in the
cell which are important for tumour cell growth and survival. Inhibition of proteasome …

During innate immune responses, proteostasis is greatly impacted by synthesis of pathogen
proteins as well as by inflammatory tissue damage through radicals or other damaging …

In cells, protein degradation is a key pathway for the destruction of abnormal or damaged
proteins as well as for the elimination of proteins whose presence is no longer required …

Proteasome inhibition is used as a treatment strategy for multiple types of cancers. Although
proteasome inhibition can induce apoptotic cell death in actively proliferating cells, it is less …

Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome
function is vulnerable to environmental insults, cellular protein imbalance and targeted …

Degradation by the proteasome is the fate for a large portion of cellular proteins, and it plays
a major role in maintaining protein homeostasis, as well as in regulating many cellular …

Proteasome is a protein degradation complex that plays a major role in maintaining cellular
homeostasis. Despite extensive efforts to identify protein substrates that are degraded …

The proteasome is present in all cells, from yeast to man, where it is central to the proteolytic
degradation of the vast majority of intracellular proteins. As such, many groups have …