MicroRNA‐155: regulation of immune cells in sepsis

M Chen, F Wang, H Xia, S Yao - Mediators of Inflammation, 2021 - Wiley Online Library
MicroRNAs are small noncoding RNAs which regulate gene expression at the
posttranscriptional level. miR‐155 is encoded by the miR‐155 host gene (miR155HG), also …

[HTML][HTML] microRNA-23b regulates the expression of inflammatory factors in vascular endothelial cells during sepsis

M Wu, JT Gu, BIN Yi, ZZ Tang… - Experimental and …, 2015 - spandidos-publications.com
Abstract miR‑23b is a multifunctional microRNA that contributes to the regulation of multiple
signaling pathways. It has been reported that miR‑23b prevents multiple autoimmune …

Inhibition of microRNA 195 prevents apoptosis and multiple-organ injury in mouse models of sepsis

D Zheng, Y Yu, M Li, G Wang, R Chen… - The Journal of …, 2016 - academic.oup.com
Background. MicroRNAs (miRs) are a class of short RNA molecules, which negatively
regulate gene expression. The levels of circulating miR-15 family members are elevated in …

Inhibition of miR-155 alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-κB signaling

YY Cao, Z Wang, ZH Wang, XG Jiang, WH Lu - International …, 2021 - Elsevier
Abstract MicroRNA-155 (miR-155) is implicated in the pathological processes of sepsis.
However, the function and regulatory mechanism of miR-155 in sepsis-induced …

[HTML][HTML] MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction

H Guo, L Tang, J Xu, C Lin, X Ling, C Lu… - European journal of …, 2019 - Springer
Background Sepsis leads to severe inflammatory and cardiac dysfunction. This study aimed
to explore the clinical value of miR-495 in sepsis, as well as its role in sepsis-induced …

MicroRNA-223 modulates the IL-4-medicated macrophage M2-type polarization to control the progress of sepsis

X Wang, H Zhang, R Guo, X Li, H Liu, Z Wang… - International …, 2021 - Elsevier
MicroRNAs play a variety of roles in the progress of inflammation. Herein, we investigated
the roles of miR-223 in governing macrophage polarization balance in the progress of …

[HTML][HTML] microRNA‑15a‑5p participates in sepsis by regulating the inflammatory response of macrophages and targeting TNIP2

Y Lou, Z Huang - Experimental and therapeutic …, 2020 - spandidos-publications.com
The mortality rate for patients experiencing sepsis is decreasing; however, an effective
therapeutic strategy requires further investigation. Increasing evidence has supported the …

[HTML][HTML] MicroRNA Fingerprints Identify miR-150 as a Plasma Prognostic Marker in Patients with Sepsis

C Vasilescu, S Rossi, M Shimizu, S Tudor, A Veronese… - PloS one, 2009 - journals.plos.org
Background The physiopathology of sepsis continues to be poorly understood, and despite
recent advances in its management, sepsis is still a life-threatening condition with a poor …

[HTML][HTML] MicroRNA-181b regulates NF-κB–mediated vascular inflammation

X Sun, B Icli, AK Wara, N Belkin, S He… - The Journal of …, 2012 - Am Soc Clin Investig
EC activation and dysfunction have been linked to a variety of vascular inflammatory
disease states. The function of microRNAs (miRNAs) in vascular EC activation and …

Detection of microRNAs in patients with sepsis

MA Puskarich, U Nandi, NI Shapiro, S Trzeciak… - Journal of Acute …, 2015 - Elsevier
Objective To externally validate the diagnostic and prognostic value of three previously
identified microRNAs in emergency department patients with sepsis. Methods Patients …