TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
A major constraint on the evolution of large body sizes in animals is an increased risk of
developing cancer. There is no correlation, however, between body size and cancer risk …
developing cancer. There is no correlation, however, between body size and cancer risk …
[HTML][HTML] A zombie LIF gene in elephants is upregulated by TP53 to induce apoptosis in response to DNA damage
JM Vazquez, M Sulak, S Chigurupati, VJ Lynch - Cell reports, 2018 - cell.com
Large-bodied organisms have more cells that can potentially turn cancerous than small-
bodied organisms, imposing an increased risk of developing cancer. This expectation …
bodied organisms, imposing an increased risk of developing cancer. This expectation …
Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans
LM Abegglen, AF Caulin, A Chan, K Lee, R Robinson… - Jama, 2015 - jamanetwork.com
Importance Evolutionary medicine may provide insights into human physiology and
pathophysiology, including tumor biology. Objective To identify mechanisms for cancer …
pathophysiology, including tumor biology. Objective To identify mechanisms for cancer …
Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis
Whales have 1000-fold more cells than humans and mice have 1000-fold fewer; however,
cancer risk across species does not increase with the number of somatic cells and the …
cancer risk across species does not increase with the number of somatic cells and the …
Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk
JM Vazquez, VJ Lynch - Elife, 2021 - elifesciences.org
The risk of developing cancer is correlated with body size and lifespan within species.
Between species, however, there is no correlation between cancer and either body size or …
Between species, however, there is no correlation between cancer and either body size or …
Elephant genomes reveal accelerated evolution in mechanisms underlying disease defenses
M Tollis, E Ferris, MS Campbell… - Molecular biology …, 2021 - academic.oup.com
Disease susceptibility and resistance are important factors for the conservation of
endangered species, including elephants. We analyzed pathology data from 26 zoos and …
endangered species, including elephants. We analyzed pathology data from 26 zoos and …
The regulation of aging and longevity: a new and complex role of p53
Z Feng, M Lin, R Wu - Genes & cancer, 2011 - journals.sagepub.com
p53 plays a critical role in tumor suppression. As a transcription factor, in response to stress
signals, p53 regulates its target genes and initiates stress responses, including cell cycle …
signals, p53 regulates its target genes and initiates stress responses, including cell cycle …
p53 isoform Δ113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish
J Chen, SM Ng, C Chang, Z Zhang… - Genes & …, 2009 - genesdev.cshlp.org
p53 is a well-known tumor suppressor and is also involved in processes of organismal aging
and developmental control. A recent exciting development in the p53 field is the discovery of …
and developmental control. A recent exciting development in the p53 field is the discovery of …
The real war on cancer: the evolutionary dynamics of cancer suppression
L Nunney - Evolutionary applications, 2013 - Wiley Online Library
Cancer is a disease of multicellular animals caused by unregulated cell division. The
prevailing model of cancer (multistage carcinogenesis) is based on the view that cancer …
prevailing model of cancer (multistage carcinogenesis) is based on the view that cancer …
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
S Berghmans, RD Murphey… - Proceedings of the …, 2005 - National Acad Sciences
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly
50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic …
50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic …