An adverse outcome pathway (AOP) network is an attempt to represent the complexity of
systems toxicology. This study illustrates how an AOP network can be derived and analysed …

Abstract The Adverse Outcome Pathway (AOP) concept has recently been proposed to
support a paradigm shift in regulatory toxicology testing and risk assessment. This concept is …

Adverse outcome pathways (AOPs) and their networks are important tools for the
development of mechanistically based non-animal testing approaches, such as in vitro …

Abstract The Adverse Outcome Pathway (AOP) framework provides a template that
facilitates understanding of complex biological systems and the pathways of toxicity that …

Organization of existing and emerging toxicological knowledge into adverse outcome
pathway (AOP) descriptions can facilitate greater application of mechanistic data, including …

Abstract Motivation Adverse outcome pathways (AOPs) are a conceptual framework
developed to support the use of alternative toxicology approaches in the risk assessment …

Abstract The Adverse Outcome Pathway (AOP) framework describes the progression of a
toxicity pathway from molecular perturbation to population-level outcome in a series of …

Neurotoxicology is the study of adverse effects on the structure or function of the developing
or mature adult nervous system following exposure to chemical, biological, or physical …

Adverse outcome pathways (AOPs) are pragmatic tools in toxicology and risk assessment
with broad potential. AOPs are designed to provide a clear-cut mechanistic representation of …

A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of
toxicological hazard information for most compounds. Therefore, new approaches are being …