Bottlenecks in the efficient use of advanced therapy medicinal products based on mesenchymal stromal cells

N Escacena, E Quesada-Hernández… - Stem cells …, 2015 - Wiley Online Library
Mesenchymal stromal cells (MSCs) have been established as promising candidate sources
of universal donor cells for cell therapy due to their contributions to tissue and organ …

[PDF][PDF] Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis

J Michalek, R Moster, L Lukac, K Proefrock… - Cell Transplant, 2015 - stem-art.com
Stromal vascular fraction (SVF), containing large amount of stem cells and other
regenerative cells, can be easily obtained from loose connective tissue that is associated …

[HTML][HTML] Challenges and strategies for improving the regenerative effects of mesenchymal stromal cell-based therapies

S Baldari, G Di Rocco, M Piccoli, M Pozzobon… - International journal of …, 2017 - mdpi.com
Cell-based therapies have the potential to revolutionize current treatments for diseases with
high prevalence and related economic and social burden. Unfortunately, clinical trials have …

Characterization of adipose tissue-derived stromal vascular fraction for clinical application to cartilage regeneration

Y Jang, YG Koh, YJ Choi, SH Kim, DS Yoon… - In Vitro Cellular & …, 2015 - Springer
Bone marrow concentration (BMC) is the most recognized procedure to prepare
mesenchymal stem cells for cartilage regeneration. However, bone marrow aspiration is …

Higher pericyte content and secretory activity of microfragmented human adipose tissue compared to enzymatically derived stromal vascular fraction

B Vezzani, I Shaw, H Lesme, L Yong… - Stem cells …, 2018 - academic.oup.com
Autologous adipose tissue is used for tissue repletion and/or regeneration as an intact
lipoaspirate or as enzymatically derived stromal vascular fraction (SVF), which may be first …

Critical steps in the isolation and expansion of adipose-derived stem cells for translational therapy

S Riis, V Zachar, S Boucher, MC Vemuri… - Expert reviews in …, 2015 - cambridge.org
Since the discovery of adipose-derived stem cells (ASCs), there have been high
expectations of their putative clinical use. Recent advances support these expectations, and …

[HTML][HTML] Safety of adipose-derived cell (stromal vascular fraction–SVF) augmentation for surgical breast reconstruction in cancer patients

S Mazur, A Zołocińska, K Siennicka… - … in Clinical and …, 2018 - advances.umw.edu.pl
Background. Progress in breast cancer surgery results in a decreased frequency of
mastectomy, in the early phases of cancer replaced by breast conserving therapy …

Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells

MJO Varma, RGM Breuls, TE Schouten… - Stem cells and …, 2007 - liebertpub.com
Adipose tissue contains a stromal vascular fraction (SVF) that is a rich source of adipose
tissue-derived stem cells (ASCs). ASCs are multipotent and in vitro-expanded ASCs have …

[HTML][HTML] Clinical use of adipose-derived stem cells: European legislative issues

E Raposio, RG Ciliberti - Annals of medicine and surgery, 2017 - Elsevier
Objective With this study we analyse the current European legislation in order to provide
guidance for regenerative medicine professionals on correct Adipose-derived Stem Cells …

Adipose extracellular matrix/stromal vascular fraction gel: a novel adipose tissue–derived injectable for stem cell therapy

Y Yao, Z Dong, Y Liao, P Zhang, J Ma… - Plastic and …, 2017 - journals.lww.com
Background: Adipose-derived stem cells and other stromal vascular fraction cells were used
more often for stem cell therapy, even though limitations such as poor cell retention rate …