Background Recently, depression has been identified as a prevalent and severe mental
disorder. However, the mechanisms underlying the depression risk remain elusive. The …

The aim of the study was to investigate the effects and possible underlying mechanism of
salidroside (Sal) on lipopolysaccharide (LPS)-induced depression-like behavior in mice. Sal …

Rationale and objectives Dl-3-n-Butylphthalide (NBP), a small molecule compound
extracted from the seeds of Apium graveolens, possesses a large range of biological effects …

In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and
neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence …

Previous studies have demonstrated that lycopene possesses anti-inflammatory properties
in the central nervous system. However, the potential role and the molecular mechanisms of …

Background The NLRP3 inflammasome activation and neuroinflammation are known to be
involved in the pathology of depression, whereas autophagy has multiple effects on …

Neuroinflammation is one of the main causes of sickness and depressive-like behavior.
Rosmarinic acid (RA) has been shown to have a significant anti-neuroinflammatory effect …

The excessive activation of microglia plays a key role in the pathogenesis of
neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been …

Oxido-nitrosative stress, neuroinflammation, and reduced level of neurotrophins are
implicated in the pathophysiology of anxiety and depressive illness. A few recent studies …

Recent studies have demonstrated the intimate relationship between depression and
immune disturbances. Aware of the efficacy limits of existing antidepressant drugs and the …