Heart failure (HF) can be defined physiologically as an inability of the heart to provide
sufficient forward output to meet the perfusion and oxygenation requirements of the tissues …

Diastolic dysfunction has been increasingly recognised as a major factor in reduced
exercise tolerance and symptoms of dyspnoea both in heart failure with reduced as well as …

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It is now well established that among patients with the clinical syndrome of heart failure (HF),
approximately half have preserved systolic function, known most commonly as heart failure …

Heart failure (HF) has traditionally been divided into HF with a reduced ejection fraction (EF;
systolic HF) and HF with a normal EF (diastolic HF). Both groups have reductions in exercise …

With an estimated 50%(range 40%–71%) of all patients with clinical symptoms of heart
failure (HF) having normal or near normal left ventricular (LV) ejection fractions (LVEF), 1–5 …

At present, heart failure with preserved ejection fraction (HFpEF) is a commonly accepted
condition in HF patients. In contrast to HF with reduced EF (HFrEF), HFpEF is strongly …

Clinical experience of the last 2 decades has shown that the prognosis of heart failure (HF)
has improved when the ejection fraction (EF) is reduced (HFREF), but not when the EF is …

Heart failure is a clinical spectrum with a similar presentation regardless of ejection fraction.
To add historical perspective, the recognition of diastolic dysfunction as a distinct clinical …

Background Patients with heart failure and preserved ejection fraction (HFpEF) display
impaired heart rate and vascular reserve with exercise, but it remains unknown to what …