Environmental chemicals, which are known to impact offspring health, have become a public
concern. Constitutive activated receptor (CAR) is activated by various environmental …

Humans are exposed to different kinds of environmental contaminants or drugs throughout
their lifetimes. The widespread presence of these compounds has raised concerns about the …

Exposure to environmental endocrine disruptors (EEDs) has become a global health
concern, and EEDs are known to be potent inducers of constitutive androstane receptor …

Hepatic induction in response to drugs and environmental chemicals affects drug therapies
and energy metabolism. We investigated whether the induction is transmitted to the …

Constitutive androstane receptor (CAR) is a nuclear receptor that not only regulates drug-
metabolizing enzymes but also influences energy metabolism. TC, 1, 4-bis [2-(3, 5 …

Safety concerns have emerged regarding the potential long-lasting effects due to
developmental exposure to xenobiotics. The pregnane X receptor (PXR) and constitutive …

More than half of pregnant women use prescription medications in order to maintain both
maternal and fetal health. The constitutive androstane receptor (Car) critically affects the …

Perinatal exposure to environmental chemicals is proposed to reprogram development and
alter disease susceptibility later in life. Supporting this, neonatal activation of the nuclear …

Safety concerns have emerged regarding the potential long-lasting effects due to
developmental exposure to xenobiotics. The pregnane X receptor (PXR) and constitutive …

Abstract Background & Aims The constitutive androstane receptor (CAR) is a nuclear
receptor that binds diverse xenobiotics and whose activation leads to the modulation of the …