Guanylate-binding protein-dependent noncanonical inflammasome activation prevents Burkholderia thailandensis-induced multinucleated giant cell formation
Inflammasomes are cytosolic multiprotein signaling complexes that are activated upon
pattern recognition receptor-mediated recognition of pathogen-derived ligands or …
pattern recognition receptor-mediated recognition of pathogen-derived ligands or …
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling
Inflammasomes are cytosolic signaling complexes capable of sensing microbial ligands to
trigger inflammation and cell death responses. Here, we show that guanylate-binding …
trigger inflammation and cell death responses. Here, we show that guanylate-binding …
Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation
Guanylate-binding proteins (GBPs) are essential components of cell-autonomous immunity.
In response to IFN signaling, GBPs are expressed in the cytoplasm of immune and …
In response to IFN signaling, GBPs are expressed in the cytoplasm of immune and …
Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion
Innate immunity responds to pathogens by producing alarm signals and activating pathways
that make host cells inhospitable for pathogen replication. The intracellular bacterium …
that make host cells inhospitable for pathogen replication. The intracellular bacterium …
Guanylate-binding proteins at the crossroad of noncanonical inflammasome activation during bacterial infections
MTR Gomes, DM Cerqueira… - Journal of leukocyte …, 2019 - academic.oup.com
The immune system is armed with a broad range of receptors to detect and initiate the
elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a …
elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a …
Interferon-induced guanylate-binding proteins in inflammasome activation and host defense
Traditional views of the inflammasome highlight the assembly of pre-existing core
components shortly after infection or tissue damage. Emerging work, however, suggests that …
components shortly after infection or tissue damage. Emerging work, however, suggests that …
Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation
AR Bass, MS Egan, J Alexander-Floyd… - Mbio, 2023 - Am Soc Microbiol
The inflammasome is essential for host defense against intracellular bacterial pathogens,
including Legionella pneumophila, the causative agent of the severe pneumonia …
including Legionella pneumophila, the causative agent of the severe pneumonia …
Irgm2 and Gate‐16 cooperatively dampen Gram‐negative bacteria‐induced caspase‐11 response
E Eren, R Planès, S Bagayoko, PJ Bordignon… - EMBO …, 2020 - embopress.org
Abstract Inflammatory caspase‐11 (rodent) and caspases‐4/5 (humans) detect the Gram‐
negative bacterial component LPS within the host cell cytosol, promoting activation of the …
negative bacterial component LPS within the host cell cytosol, promoting activation of the …
IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection
P Wallet, S Benaoudia, A Mosnier, B Lagrange… - PLoS …, 2017 - journals.plos.org
Guanylate binding proteins (GBPs) are interferon-inducible proteins involved in the cell-
intrinsic immunity against numerous intracellular pathogens. The molecular mechanisms …
intrinsic immunity against numerous intracellular pathogens. The molecular mechanisms …
IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes
The inflammasome is an intracellular signaling complex, which on recognition of pathogens
and physiological aberration, drives activation of caspase-1, pyroptosis, and the release of …
and physiological aberration, drives activation of caspase-1, pyroptosis, and the release of …