Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1 …
RI Connor, H Mohri, Y Cao, DD Ho - Journal of virology, 1993 - Am Soc Microbiol
The rate of clinical progression is variable among individuals infected with human
immunodeficiency virus type 1 (HIV-1). Changes in viral burden which correlate with disease …
immunodeficiency virus type 1 (HIV-1). Changes in viral burden which correlate with disease …
Loss of CD4+ T Cell Proliferative Ability but Not Loss of Human Immunodeficiency Virus Type 1 Specificity Equates with Progression to Disease
JDK Wilson, N Imami, A Watkins, J Gill… - The Journal of …, 2000 - academic.oup.com
In this study, we compared human immunodeficiency virus (HIV) type 1—specific
proliferative responses with HIV-1—induced intracellular cytokine production in a cohort of …
proliferative responses with HIV-1—induced intracellular cytokine production in a cohort of …
Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy
M Rehr, J Cahenzli, A Haas, DA Price… - Journal of …, 2008 - Am Soc Microbiol
Progressive human immunodeficiency virus type 1 (HIV-1) infection is often associated with
high plasma virus load (pVL) and impaired CD8+ T-cell function; in contrast, CD8+ T cells …
high plasma virus load (pVL) and impaired CD8+ T-cell function; in contrast, CD8+ T cells …
Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype
PTA Schellekens, M Tersmette, MTL Roos, RP Keet… - Aids, 1992 - journals.lww.com
Objective: To determine the kinetics of decline of CD4+ lymphocytes in HIV-1-infected
asymptomatic homosexual men. Methods: CD4+ lymphocytes were enumerated in a cohort …
asymptomatic homosexual men. Methods: CD4+ lymphocytes were enumerated in a cohort …
Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease
SK Choudhary, N Vrisekoop, CA Jansen… - Journal of …, 2007 - Am Soc Microbiol
Long-term asymptomatic human immunodeficiency virus (HIV)-infected individuals (LTA)
usually have low viral load and low immune activation. To discern whether viral load or …
usually have low viral load and low immune activation. To discern whether viral load or …
Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection
L Musey, J Hughes, T Schacker, T Shea… - … England Journal of …, 1997 - Mass Medical Soc
Background Early in human immunodeficiency virus type 1 (HIV-1) infection there is a
decline in viral replication that has been attributed to host immunity, but the components of …
decline in viral replication that has been attributed to host immunity, but the components of …
Longitudinal analysis of quantitative virologic measures in human immunodeficiency virus-infected subjects with⩾ 400 CD4 lymphocytes: implications for applying …
WB Paxton, RW Coombs, MJ McElrath… - Journal of Infectious …, 1997 - academic.oup.com
The natural variability of quantitative virologic measures among human immunodeficiency
virus (HIV) type 1-infected persons was prospectively studied in 29 untreated persons with> …
virus (HIV) type 1-infected persons was prospectively studied in 29 untreated persons with> …
Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy
SA Migueles, KA Weeks, E Nou, AM Berkley… - Journal of …, 2009 - Am Soc Microbiol
Identifying the functions of human immunodeficiency virus (HIV)-specific CD8+ T cells that
are not merely modulated by the level of virus but clearly distinguish patients with immune …
are not merely modulated by the level of virus but clearly distinguish patients with immune …
Distinct Transcriptional Profiles in Ex Vivo CD4+ and CD8+ T Cells Are Established Early in Human Immunodeficiency Virus Type 1 Infection and Are Characterized by a …
MD Hyrcza, C Kovacs, M Loutfy, R Halpenny… - Journal of …, 2007 - Am Soc Microbiol
Changes in T-cell function are a hallmark of human immunodeficiency virus type 1 (HIV-1)
infection, but the pathogenic mechanisms leading to these changes are unclear. We …
infection, but the pathogenic mechanisms leading to these changes are unclear. We …
T cell dynamics in HIV-1 infection
DC Douek, LJ Picker, RA Koup - Annual review of immunology, 2003 - annualreviews.org
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …
infection of the human immune system that invariably, over the course of years, leads to its …