Introduction Stroke is one of the leading causes of mortality and morbidity globally. Atrial
fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic …

Background Even on optimal therapy including anticoagulation and rate control, major
cardiovascular complications (stroke, cardiovascular death, and acute heart failure) are …

Atrial fibrillation (AF) is the most common sustained clinical arrhythmia, with a lifetime
incidence of up to 37%, and is a major contributor to population morbidity and mortality …

The last three decades have been characterized by an exponential increase in knowledge
and advances in the clinical management of atrial fibrillation. The purpose of the study is to …

A bidirectional pathophysiological link connects heart failure and atrial fibrillation, creating a
frequent and challenging comorbidity, which includes neurohormonal hyperactivation …

896 Stroke March 2016 risk. However, in a meta-analysis of 8 randomized clinical trials, a
rhythm-control strategy had no effect on stroke risk (odds ratio, 0.99; 95% confidence …

AF increases the risk of stroke sixfold and is associated with a twofold increase in mortality,
which remains above 1.5-fold after adjusting for co-morbidity, predominantly caused by …

Atrial fibrillation (AF) is the most frequently encountered cardiac arrhythmia. The trigger for
initiation of AF is generally an enhanced vulnerability of pulmonary vein cardiomyocyte …

Evidence is emerging to indicate that atrial fibrillation (AF) is independently associated with
an increased risk of sudden cardiac death (SCD). This association has been consistently …

Atrial fibrillation is the most common sustained cardiac rhythm disorder, and confers a
substantial mortality and morbidity from stroke, thromboembolism, heart failure, and …