Hypoxia inducible factor 1 (HIF-1), a key regulator for adaptation to hypoxia, is composed of
HIF-1α and HIF-1β. In this study, we present evidence that overexpression of mitochondria …

Hypoxia-inducible factors (HIFs) are activated in parenchymal cells in response to low
oxygen and as such have been proposed as therapeutic targets during hypoxic insult …

Cardiovascular (CV) diseases are the major cause of death in industrialized countries. The
main function of the CV system is to deliver nutrients and oxygen to all tissues. During most …

Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …

Hypoxic/ischemic conditions provoke activation of the hypoxia-inducible factor-1 (HIF-1),
which functions as a transcription factor. HIF-1 is composed of the HIF-1α and-β subunits …

Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct
multiple cellular and systemic responses in response to changes in oxygen availability. The …

Tissue hypoxia is a pathologic feature of many human diseases including cancer,
myocardial infarction, stroke, and kidney disease. An evolutionarily conserved oxygen …

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …

Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of
many genes induced under low oxygen conditions. Under normal oxygen conditions, HIF …

The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia
in humans, but it is unknown whether this activation of HIF persists during chronic heart …