Cells sense and respond to hypoxia through the activity of the transcription factor HIF
(hypoxia-inducible factor) and its regulatory hydroxylases, the prolyl hydroxylase domain …

The kidney is sensitive to changes in oxygen delivery. This sensitivity has the merit of
facilitating the kidneys in their adjustment of erythropoietin (EPO) production to changes in …

Oxygen is vital to mammalian survival. Oxygen deprivation, defined as hypoxia, elicits
adaptive responses in cells and tissues, a process regulated by proteins known as hypoxia …

Background: Hypoxia inducible factors (HIFs) are transcription factors that are regulated by
HIF-prolyl 4-hydroxylases (PHDs) in response to changes in oxygen tension. Once …

Liver disease is a growing global health problem, as deaths from end-stage liver cirrhosis
and cancer are rising across the world. At present, pharmacologic approaches to effectively …

The heterodimeric hypoxia‐inducible factor (HIF)‐1 is a master transcriptional regulator of
oxygen homeostasis and a possible target for gene therapy of ischemic disease. Although …

The oxygen-sensitive hypoxia-inducible factor (HIF) pathway plays a central role in the
control of erythropoiesis and iron metabolism. The discovery of prolyl hydroxylase domain …

Abstract Aim Hypoxia‐inducible factors (HIFs) are O2‐sensitive transcription factors that
regulate multiple biological processes which are essential for cellular adaptation to hypoxia …

Effective vascular regeneration could provide therapeutic benefit for multiple pathologies,
especially in chronic peripheral artery disease (PAD) and myocardial ischemia. The hypoxia …

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …