Rats trained to perform a version of the rat gambling task (rGT) in which salient audiovisual
cues accompany reward delivery, similar to commercial gambling products, show greater …

Background Both psychostimulant use and engagement with probabilistic schedules of
reward sensitize the mesocorticolimbic dopamine (DA) system. Such behaviors may act …

Similar to other addiction disorders, the cues inherent in many gambling procedures are
thought to play an important role in mediating their addictive nature. Animal models of …

Maladaptive decision‐making may play an integral role in the development and
maintenance of an addiction. Substance‐dependent individuals make riskier choices on the …

Chronic exposure to drugs of abuse is linked to long-lasting alterations in the function of
limbic system structures, including the nucleus accumbens (NAc). Although cocaine acts via …

Drug-associated cues can acquire powerful motivational control over the behavior of
addicts, and can contribute to relapse via multiple, dissociable mechanisms. Most preclinical …

Dorsal lateral striatum (DLS) is a highly associative structure that encodes relationships
among environmental stimuli, behavioral responses, and predicted outcomes. DLS is known …

Addiction is characterized by persistent drug-seeking despite adverse consequences or
outcomes. Such persistent behavior may result from drug-induced brain changes that …

Addiction is a disorder of behavioral control and learning. While this may reflect pre-existing
propensities, drug use also clearly contributes by causing changes in outcome processing in …

The similarity between gambling disorder (GD) and drug addiction has recently been
recognized at the diagnostic level. Understanding the core cognitive processes involved in …