Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the
development and maintenance of addiction. Rodent studies suggest that this sensitivity is …

Heightened sensation seeking is associated with an increased risk of substance use
disorder in clinical populations. In rats, sensation seeking is often examined by measuring …

Cocaine addiction is characterized by impulsivity, impaired social relationships, and
abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages …

Craving is one of the primary behavioral components of drug addiction, and cue-elicited
craving is an especially powerful form of this construct. While cue-elicited craving and its …

Although the dopamine transporter (DAT) is the primary site of action for cocaine, and the
dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic …

A variety of evidence suggests important commonalities in the neurochemical basis of
reinforcement in pathological gambling (PG) and psychostimulant addiction. This article …

Approach to reward is a fundamental adaptive behavior, disruption of which is a core
symptom of addiction and depression. Nucleus accumbens (NAc) dopamine is required for …

Dopamine (DA) is critical for reward processing, but significantly less is known about its role
in punishment avoidance. Using a combined approach-avoidance task, we measured …

Although there is increasing clinical recognition of behavioral addictions, of which gambling
disorder is the prototype example, there is a limited understanding of the psychological …

Rationale Pairing rewarding outcomes with audiovisual cues in simulated gambling games
increases risky choice in both humans and rats. However, the cognitive mechanism through …