Tumour evolution in hepatocellular carcinoma
AJ Craig, J Von Felden, T Garcia-Lezana… - Nature reviews …, 2020 - nature.com
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically
develops on the background of chronic liver disease and is an aggressive disease with …
develops on the background of chronic liver disease and is an aggressive disease with …
[HTML][HTML] Cellular heterogeneity and plasticity in liver cancer
LK Chan, YM Tsui, DWH Ho, IOL Ng - Seminars in cancer biology, 2022 - Elsevier
Hepatocarcinogenesis involves complex genetic and cellular dysregulations which drive the
formation of hepatocellular carcinoma (HCC), the predominant form of primary liver cancer …
formation of hepatocellular carcinoma (HCC), the predominant form of primary liver cancer …
Tumor heterogeneity in hepatocellular carcinoma: facing the challenges
LC Lu, CH Hsu, C Hsu, AL Cheng - Liver cancer, 2016 - karger.com
Tumor heterogeneity in hepatocellular carcinoma (HCC), such as that found in second
primary tumors after curative treatment, synchronous multifocal tumors of different clonality …
primary tumors after curative treatment, synchronous multifocal tumors of different clonality …
Genetics of hepatocellular carcinoma: approaches to explore molecular diversity
Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies with different
risk factors, including alcohol abuse, chronic hepatitis B virus (HBV) and hepatitis C virus …
risk factors, including alcohol abuse, chronic hepatitis B virus (HBV) and hepatitis C virus …
[HTML][HTML] The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers.
Using multi-regional sampling of nine resected HCC with different aetiologies, here we …
Using multi-regional sampling of nine resected HCC with different aetiologies, here we …
Molecular subtyping of hepatocellular carcinoma: A step toward precision medicine
Y Wu, Z Liu, X Xu - Cancer Communications, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most prevalent and fatal digestive tumors.
Treatment for this disease has been constraint by heterogeneity of this group of tumors …
Treatment for this disease has been constraint by heterogeneity of this group of tumors …
Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Background & Aims Intratumor molecular heterogeneity is a key feature of tumorigenesis
and is linked to treatment failure and patient prognosis. Herein, we aimed to determine what …
and is linked to treatment failure and patient prognosis. Herein, we aimed to determine what …
[HTML][HTML] Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing
M Duan, J Hao, S Cui, DL Worthley, S Zhang, Z Wang… - Cell research, 2018 - nature.com
Hepatocellular carcinoma (HCC) is a cancer of substantial morphologic, genetic and
phenotypic diversity. Yet we do not understand the relationship between intratumor …
phenotypic diversity. Yet we do not understand the relationship between intratumor …
[HTML][HTML] Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits
Background & Aims Human hepatocarcinogenesis is as a multi-step process starting from
dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC) …
dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC) …
[HTML][HTML] The significance of intertumor and intratumor heterogeneity in liver cancer
Genomic analyses of primary liver cancer samples reveal a complex mutational landscape
with vast intertumor and intratumor heterogeneity. Different primary liver tumors and …
with vast intertumor and intratumor heterogeneity. Different primary liver tumors and …
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- hepatocellular carcinoma clonal evolution
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- hepatocellular carcinoma spatial organization
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- hepatocellular carcinoma precision medicine
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