Since the discovery of alternative splicing in the late 1970s, a great number of alternatively
spliced transcripts have emerged; this number has exponentially increased with the …

Alternative splicing is a major cellular mechanism in metazoans for generating proteomic
diversity. A large proportion of protein-coding genes in multicellular organisms undergo …

Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of
proteins in humans, causing a diversity of expression of transcriptomes and proteomes in a …

Alternative splicing is a fundamental, evolutionarily conserved process that vastly expands
the coding power of genomes. Alternative splicing regulation is a key step in gene …

Alternative splicing is a major source of diversity in the human proteome. The regulation of
alternative splicing modulates the composition of this diversity to fulfill the physiological …

Alternative splicing is a key process of multi-exonic gene expression during pre-mRNA
maturation. In this process, particular exons of a gene will be included within or excluded …

Recent genome-wide analyses of alternative splicing indicate that 40–60% of human genes
have alternative splice forms, suggesting that alternative splicing is one of the most …

Alternative splicing is an important mechanism to regulate gene expression and to expand
the repertoire of gene products in order to accommodate an increase in complexity of …

Pre-mRNA splicing is an essential RNA processing step in eukaryotes. Alternative splicing
generates distinct spliced isoforms of the same gene, thereby dramatically increasing …

Alternative splicing of pre-messenger RNA (pre-mRNA) is a fundamental mechanism of
gene regulation in higher eukaryotes. In addition to creating protein diversity, alternative …