BackgroundFor patients with major depressive disorder (MDD) experiencing side-effects or
non-response to their first antidepressant, little is known regarding the effect of switching …

Objective: Selective serotonin reuptake inhibitors (SSRIs) are frequently used as a first
antidepressant for major depressive disorder but have response rates of 50% to 60% in …

Objective: An antidepressant medication switch often follows a failed initial trial with
selective serotonin reuptake inhibitors (SSRIs). When, for whom, and how often second-step …

If a patient with major depressive disorder has not responded after an adequate trial of an
antidepressant medication, switching to another antidepressant of the same class or a …

Background: Comparative evidence for second-step treatment strategies in severe
depression is scarce. Up-titrating a well tolerated selective serotonin reuptake inhibitor …

Objective Antidepressant switch is a commonly used strategy in the absence of an adequate
response, but optimum timing is not well established. We compared the efficacy of an early …

Aims: To investigate switching patterns of major antidepressant treatments and associated
factors in a primary care adult population with major depressive disorder (MDD) using data …

Objective: Non-response to antidepressant treatment is a substantial problem in primary
care, and many patients with depression require additional second-line treatments. This …

Bschor T, Baethge C. No evidence for switching the antidepressant: systematic review and
meta‐analysis of RCTs of a common therapeutic strategy. Objective: Switching …

Background Switching antidepressant medications is recommended when an initial
antidepressant is not effective, when it is unable to be tolerated or when there are significant …